|Galega officinalis flowers|
Galega officinalis, commonly known as goat's rue, French lilac, Italian fitch or professor-weed, is an herbaceous plant in the Faboideae subfamily. It is native to the Middle East, but it has been naturalised in Europe, western Asia, and western Pakistan. The plant has been extensively cultivated as a forage crop, an ornamental, a bee plant and as green manure. Its name derives from gale (milk) and ega (to bring on), as Galega has been used as a galactogogue in small domestic animals (hence the name "Goat's rue"). Galega bicolor is a synonym. It is a hardy perennial that blooms in the summer months.
In 1891, goat's rue was introduced to Cache County, Utah, for use as a forage crop. It escaped cultivation and is now a weed and agricultural pest, though it is still confined to that county. As a result it has been placed on the Federal Noxious Weed List in the United States. It was collected in Colorado, Connecticut and New York prior to the 1930s, and in Maine and Pennsylvania in the 1960s, but no more collections have been made in these areas since and the populations are presumed to have died out. It has also been found in Argentina, Chile, Ecuador, and New Zealand.
Galega officinalis has been known since the Middle Ages for relieving the symptoms of diabetes mellitus. Upon analysis, it turned out to contain compounds related to guanidine, a substance that decreases blood sugar by mechanisms including a decrease in insulin resistance, but were too toxic for human use. Georges Tanret identified an alkaloid from this plant, galegine, that was less toxic, and this was evaluated in unsuccessful clinical trials in patients with diabetes in the 1920s and 1930s.
Other related compounds were being investigated clinically at this time, including biguanide derivatives. This work led ultimately to the discovery of metformin (Glucophage), currently recommended in international guidelines for diabetes management as the first choice for antidiabetic pharmacotherapy alongside diet and exercise, and the older agent phenformin, which has been withdrawn in most countries due to an unacceptable risk of lactic acidosis (the risk of lactic acidosis with metformin is no higher than with other antidiabetic therapies when it is prescribed according to its label). The study of galegine and related molecules in the first half of the 20th century is regarded as an important milestone in the development of oral antidiabetic pharmacotherapy.
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