Gallamine triethiodide

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Gallamine triethiodide
Gallamine triethiodide.svg
Systematic (IUPAC) name
2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide
Clinical data
Trade names Flaxedil
AHFS/Drugs.com International Drug Names
Legal status
?
Identifiers
CAS number 65-29-2 YesY
ATC code M03AC02
PubChem CID 6172
IUPHAR ligand 356
DrugBank DB00483
ChemSpider 5937 N
UNII Q3254X40X2 YesY
KEGG D02292 YesY
ChEBI CHEBI:503442 YesY
ChEMBL CHEMBL1200993 N
Chemical data
Formula C30H60N3O3+3 · 3 I- (gallamine triethiodide)
C24H45N3O3 (gallamine)
Mol. mass 891.529 g/mol (gallamine triethiodide)
423.633 g/mol
(gallamine)
 N (what is this?)  (verify)

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.[3]

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

An ampoule of gallamine.

References[edit]