gamma-Hydroxyvaleric acid

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gamma-Hydroxyvaleric acid
4-Hydroxyvaleric acid.svg
Systematic (IUPAC) name
4-Hydroxyvaleric acid
Clinical data
  • Uncontrolled
PubChem CID 114539
ChemSpider 102591
Synonyms γ-Hydroxyvaleric acid
Chemical data
Formula C5H10O3
118.13 g/mol

γ-Hydroxyvaleric acid (GHV), also known as 4-methyl-GHB, is a designer drug related to γ-hydroxybutyric acid (GHB). It is sometimes seen on the black market as a legal alternative to GHB, but with lower potency and higher toxicity,[1] properties which have tended to limit its recreational abuse.[2]

γ-Valerolactone (GVL) acts as a prodrug to GHV, analogously to how γ-butyrolactone (GBL) is a prodrug to GHB.[3]

See also[edit]


  1. ^ Carter LP; Chen W; Wu H; Mehta AK; Hernandez RJ; Ticku MK; Coop A; Koek W; France CP (April 2005). "Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV)". Drug and Alcohol Dependence 78 (1): 91–9. doi:10.1016/j.drugalcdep.2004.10.002. PMID 15769562. 
  2. ^ Fred Smith (31 December 2004). Handbook of Forensic Drug Analysis. Academic Press. pp. 462–. ISBN 978-0-08-047289-8. 
  3. ^ Andresen-Streichert H, Jungen H, Gehl A, Müller A, Iwersen-Bergmann S (2013). "Uptake of gamma-valerolactone--detection of gamma-hydroxyvaleric acid in human urine samples". J Anal Toxicol 37 (4): 250–4. doi:10.1093/jat/bkt013. PMID 23486087.