Carboxyglutamic acid

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Carboxyglutamic acid
Carboxyglutamic acid.png
CAS number 53445-96-8
PubChem 40772
ChemSpider 37241
Jmol-3D images Image 1
Molecular formula C6H9NO6
Molar mass 191.14 g/mol
Density 1.649 g/mL
Boiling point 418 °C (784 °F; 691 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, Vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, X and protein Z.[1]


  1. ^ J Stenflo, and J W Suttie. "Vitamin K-Dependent Formation of γ-Carboxyglutamic Acid". Annual Review of Biochemistry 46: 157–172. doi:10.1146/ 

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