Carboxyglutamic acid

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Carboxyglutamic acid
Carboxyglutamic acid.png
IUPAC name
3-Aminopropane-1,1,3-tricarboxylic acid
Other names
ChemSpider 37241
Jmol-3D images Image
PubChem 40772
Molar mass 191.14 g/mol
Density 1.649 g/mL
Boiling point 418 °C (784 °F; 691 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, Vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, X and protein Z.[1]


  1. ^ J Stenflo, and J W Suttie. "Vitamin K-Dependent Formation of γ-Carboxyglutamic Acid". Annual Review of Biochemistry 46: 157–172. doi:10.1146/ 

See also[edit]