Ganoderic acid
| Ganoderic acid A | |
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(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R) |
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| Identifiers | |
| CAS number | 81907-62-2 |
| PubChem | 471002 |
| ChemSpider | 413668 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C30H44O7 |
| Molar mass | 516.67 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia.[1] Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection,[citation needed] anti-tumor effects,[2] and 5-alpha reductase inhibition.[3]
[edit] References
- ^ T. Mizuno, G. Wang, J. Zhang, H. Kawagishi, T. Nishitoba, J. Li. Ganoderma lucidum and Ganoderma tsugae: Bioactive substances and medicinal effects. Food Rev. Intern. (1995) 11: 151-166.
- ^ G. Wang, J. Zhao, J. Liu, Y. Huang, J.J. Zhong, W. Tang. Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. International Immunopharmacology (2007) 7: 864-870.
- ^ J. Liu, K. Kurashiki, K. Shimizu, R. Kondo. Structure-activity relationship for inhibition of 5alpha-reductase by triterpenoids isolated from Ganoderma lucidum. Bioorganic & Medicinal Chemistry (2006) 14: 8654-8660.
- ^ U. Lindequist, T.H. Niedermeyer, W.D. Jülich. The Pharmacological Potential of Mushrooms. Evidence-based Complementary and Alternative Medicine (2005) 2: 285-299.
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