Ganoderic acid

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Ganoderic acid A
Ganoderic acid.png
Names
IUPAC names
(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)
-7,15-dihydroxy-4,4,10,13,14-pentamethyl-3,
11-dioxo-2,5,6,7,12,15,16,17
-octahydro-1H-cyclopenta[a]phenanthren-17-yl]
-2-methyl-4-oxoheptanoic acid
Identifiers
81907-62-2 YesY
ChemSpider 413668 N
Jmol-3D images Image
PubChem 471002
Properties
C30H44O7
Molar mass 516.67
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia.[1] Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection,[citation needed] anti-tumor effects,[2] and 5-alpha reductase inhibition.[3]

References[edit]

  1. ^ Mizuno, T.; Wang, G.; Zhang, J.; Kawagishi, H.; Nishitoba, T.; Li, J. (1995). "Reishi, Ganoderma lucidum and Ganoderma tsugae: Bioactive substances and medicinal effects". Food Reviews International 11: 151–166. doi:10.1080/87559129509541025.  Closed access
  2. ^ Wang, G.; Zhao, J.; Liu, J.; Huang, Y.; Zhong, J. J.; Tang, W. (2007). "Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo". International Immunopharmacology 7 (6): 864–870. doi:10.1016/j.intimp.2007.02.006. PMID 17466920.  Closed access
  3. ^ Liu, J.; Kurashiki, K.; Shimizu, K.; Kondo, R. (December 2006). "Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum". Bioorganic & Medicinal Chemistry 14 (24): 8654–8660. doi:10.1016/j.bmc.2006.08.018. PMID 16962782.  Closed access