Garvan Institute of Medical Research
|Garvan Institute of Medical Research|
|Motto||Breakthrough Medical Research|
|Location||Darlinghurst, Sydney, NSW, Australia|
|Director||Professor John Mattick AO FAA|
|Affiliations||University of New South Wales|
The Garvan Institute of Medical Research was founded in 1963 by the Sisters of Charity. Initially a research department of St Vincent's Hospital in Sydney, it is now one of Australia's largest medical research institutions with approximately 650 scientists, students and support staff. The current director is Prof John Mattick.
Garvan's research is focused on the major diseases that affect today's society: cancer, diabetes, osteoporosis, Alzheimer's disease, Parkinson's disease; as well as eating disorders, and autoimmune and inflammatory conditions such as rheumatoid arthritis and asthma. It specialises in genetic and molecular technologies, and emphasises collaborative research.
In 2014 the Institute became one of only three organisations in the world able to sequence the human genome at a base cost below $US1,000 each when it purchased the next generation of genome sequencing equipment, which is capable of sequencing 350 genomes a week (18,000 a year).
- 1 History
- 2 Structure and organisation
- 3 Purpose
- 4 Research Activity
- 5 Directors
- 6 Other notable staff
- 7 Funding and fundraising
- 8 Facilities
- 9 Subsidiaries
- 10 World record attempts
- 11 References
- 12 External links
Establishment and early years
Funds for its establishment were provided by a centenary hospital appeal by the Sisters of Charity for St Vincent's Hospital. Helen Mills, the largest donor, asked for the centre to be named after her father, the late James Patrick Garvan (1843-1896), a distinguished New South Wales parliamentarian and business leader.
Construction of the original Garvan Institute building began in January 1962 on the corner of Victoria, Burton and Chaplin Streets. It consisted of a basement and three floors and allowed for the eventual development of a six floor building. The Institute was officially opened on 17 February 1963 by Bernard Marmaduke Fitzalan-Howard KG, GCVO GBE, the 16th Duke of Norfolk, with the opening ceremony attended by 1500 supporters and dignitaries.
Over the following two years, research projects were initiated, lab workers appointed, and a Management Committee established. Research during the early years was dominated by endocrinology, fostered by the presence of the State Reference Laboratory for endocrine assays. A hormone radioimmunoassay service at Garvan in 1964-1965, which was a significant component of the research activity and provided a steady source of funds, an important consideration before regular research grants were available. The late 1960s and 1970s saw the expansion of scientific staff at the Institute, including the arrival of a critical mass of key senior researchers, many of whom are now recognised as ground breakers in their field.
The 1980s: increased funding
The Garvan Research Foundation was established on 1 January 1981, with the aim: “To support, assist and promote scientific and medical research within the Garvan Institute of Medical Research”.
In 1982 the National Health and Medical Research Council (NHMRC) awarded Garvan its first Program Grant for research into diabetes, while in May 1983 the Council of the University of New South Wales approved the affiliation of the Institute with the University, which continues to this day.
The New South Wales Parliament passed the Garvan Institute of Medical Research Act in 1984, incorporating Garvan as an autonomous, non-profit research institute. In 1986, Garvan became one of only five 'centres of research excellence' in Australia to receive NHMRC 'block funding'. That, along with subsequent infrastructure funding from the NSW Government, allowed Garvan to expand into a world-class facility.
The 1990s: expansion and construction
NHMRC funding and increased public financial support through the Garvan Research Foundation allowed the Institute to increase dramatically in size throughout the 1990s.
In 1992 the Institute was awarded one of the Federal Government’s prestigious Co-operative Research Centres, to focus on the development of internationally competitive products in the biopharmaceutical field. The Centre was a joint venture between Garvan, University of New South Wales, St Vincent’s Hospital, the Biomolecular Research Institute in Melbourne, the Commonwealth Serum Laboratories, Peptide Technology Ltd and Johnson and Johnson Research Pty Ltd.
The Institute was granted a large infrastructure grant by the NSW Government in 1994, and used this funding to build the world-class research facility it is currently housed in on the site of the original Garvan building. The new building was completed in 1997, when it was opened on 7 April by Prime Minister John Howard and Bob Carr, then Premier of New South Wales.
The 21st century: the rise of 'big science'
After advances in molecular biology in the 1990s came the 'big science’ of the 21st century. The launch in 2000 of the first draft of the human genome led to huge sequence databases and gene arrays, removing the need for painstaking testing of individual gene activity. Garvan embraced this new research model quickly and, in a similar way, more recently embraced proteomics and epigenetics, as well as the bioinformatics expertise required to analyse and interpret huge datasets.
In 2003 the NHMRC awarded a prestigious and highly competitive Program Grant of $5 million to Cancer Research Program over a period of five years, forming a critical base for its continued work. In 2004 the Australian Cancer Research Foundation (ACRF) provided a grant of $1.1 million to establish a Cancer Molecular Genetics Unit in collaboration with St Vincent’s Hospital. The grant enabled the purchase of equipment to analyse genetic changes in different tumour biopsies.
The Kinghorn Cancer Centre, a $100 million joint venture between Garvan and St Vincent's Hospital, was opened on 28 August 2012 by Prime Minister Julia Gillard. The centre is named after the Kinghorn Foundation, one of the centre's main benefactors. The Kinghorn Centre for Clinical Genomics (KCCG) was also established in 2012, with a commitment of $9 million in funding from the Kinghorn Foundation. KCCG is Australia's leading medical research institute in medical genomics and informatics that translates into genome-based personalised medicine. The functions of the KCCG include high quality 'next generation' genome sequencing and diagnostic services. In 2014 it was announced that the Garvan Institute would be one of the world's first organisations to purchase the next generation of genome sequencing equipment – to be located in the KCCG – capabable of sequencing 350 genomes a week (18,000 a year) at a base cost below $US1,000 each.
Structure and organisation
The Institute is organised into five medical research divisions: Bone Biology, Cancer, Diabetes and Obesity, Immunology and Neuroscience.
Many staff from the Cancer division are based in the Kinghorn Cancer Centre, a $100 million joint initiative between Garvan and St Vincent's Hospital located next door to the Garvan building. This purpose built cancer care centre houses around 250 scientists, clinicians and support staff from both organisations, and is home to the Kinghorn Centre for Clinical Genomics.
Fundraising and marketing for the Institute is handled by the Garvan Research Foundation, whose current Chief Executive Officer is Andrew Giles. Governance of the Institute and the Foundation is overseen by two boards of directors, the Institute's board including members nominated by the Trustees of St Vincent's Hospital, the Sisters of Charity, the NSW Minister for Health and the Federal Minister for Health.
The Garvan Institute states its mission as being “…to make significant contributions to medical research that will change the directions of science and medicine and have major impacts on human health. Garvan strives to enhance and develop research programs that combine fundamental science with strong clinical interactions.”
Garvan's ultimate goal is the prevention, treatment or cure of some of the most widespread diseases currently affecting society.
The Institute’s research scope focuses on “…understanding the role of genes and molecular and cellular processes in health and disease as the basis for developing future preventions, treatments and cures.” Areas of research include:
- Diabetes and obesity
- Neurological diseases such as Alzheimer's, Parkinson's, hearing loss, mental illnesses and eating disorders
- Immunological diseases such as asthma, rheumatoid arthritis, multiple sclerosis and Sjogren’s syndrome
- 2012-present: Professor John Mattick
- 1990-2012: Professor John Shine
- 1969-1990: Dr Les Lazarus
- 1966-1969: Associate Professors John Hickie and Gerry Milton and Dr Les Lazarus
Other notable staff
- Dr Russell Howard - Commercial Strategy Advisor, Kinghorn Centre for Clinical Genomics
- Professor David James – formerly head of the Diabetes and Obesity division
- Associate Professor Amanda Salis – formerly leader of the Eating Disorders research group
Funding and fundraising
The Garvan Institute is funded from a diverse range of Government and private sources including the corporate sector, trusts and foundations and individual donors. For every dollar the Institute receives from competitive Government grants, the Garvan Research Foundations has to raise an additional 70c to carry out the research.
The Garvan Research Foundation was established in 1981 to provide fundraising support to the Institute’s medical research programs and promote its research. The Foundation has successfully grown from a fundraising base of $110,000 in its first year to around $20 million a year.
In addition to its fundraising activities, the Foundation's activities have since expanded to support the Institute with a Public Engagement Program. This initiative aims to increase understanding of the need for and importance of Garvan's medical research across the broader community.
A number of high profile public figures are involved with fundraising through the Foundation and promoting the work of the Institute: Singer/actress Delta Goodrem, a former cancer patient at St Vincent's Hospital, is Patron of the Kinghorn Cancer Centre; Journalist/media personality Tracey Spicer is the face of the Garvan’s research into pancreatic cancer, the disease responsible for her mother's death; Actor Samuel Johnson is currently riding 15,000 km on a unicycle in an attempt to break the Guinness World Record and raise $1 million for the Garvan Institute of Medical Research to find a cure for breast cancer. His stated mission is to remind every Australian woman about the need to be 'breast aware', in an effort to promote early detection and improve survival rates, via his charitable foundation, Love Your Sister.
In the latest round of National Health and Medical Research Council grants, announced in October 2013, Garvan received $15.5 million, out of a total funding pool of $559.1 million. The Institute performed well, with a success rate of 26% for project grants, well ahead of the national average of 16.9%. Garvan received 11% of funding awarded to NSW as a whole, and 2.8% of the national total.
Garvan is based in a state-of-the-art research facility designed by renowned Australian architect Ken Woolley. Incorporating the old St Vincent's Hospital Nurses Home, the building features an iconic DNA-inspired helical staircase, and a dome-covered atrium that contains several large research laboratories. The foyer-area galleria, library underneath the atrium and 300 seat NAB auditorium in the lower ground floor are used for professional and social functions by Garvan and non-Garvan groups.
The Institute’s core research facilities incorporate a range of cutting-edge equipment and expertise, with some scientific facilities used by external researchers on a pay per use basis. Garvan’s research facilities and technology platforms include the following:
- Animal Imaging
- Animal Research
- Biodata Visualisation
- Clinical Research Facility
- Flow Cytometry
- Functional genomics
- Mass Spectrometry
- Molecular Genetics
- Australian BioResources Pty Ltd (ABR) - offers agistment and allied services to Garvan and other biomedical research institutes and universities on a non-profit, full cost recovery basis.
World record attempts
On 21 October 2010 more than 150 Garvan staff and students worked with Sydney school students in a world record attempt to create the largest DNA model. They created a model that was the exact replica of the human Neuropeptide Y (NPY) gene measuring 25.66m in length, breaking the previous world record held by Konan University in Kobe, Japan.
To meet Guinness World Records guidelines Garvan had to follow the exact gene sequence for the NPY gene, which includes 1,300 base pairs (the basic elements of the genetic code used by all organisms to make proteins).
On 14 February 2013 actor Samuel Johnson began a year long, 15,000km world record attempt to travel the longest distance on a unicycle, which he undertook to raise funds for breast cancer research at the Garvan Institute and raise public breast cancer awareness following his sister's diagnosis with the disease.
On 14 February 2014 Johnson returned to the starting point of his journey, Melbourne's Federation Square, having travelled 15,955km by unicycle, broken the world record for the longest unicycle journey and raised $1,477,630.
- Herper, Matthew. "The $1,000 Genome Arrives -- For Real, This Time". magazine. Forbes. Retrieved 19 February 2014.
- "The future of genomic medicine has arrived in Australia". Media Release. Garvan Institute. Retrieved 21 January 2014.
- "PM opens new Sydney cancer centre". News Website. 9MSN. Retrieved 22 January 2014.
- Turner, Brook. "No-regrets Kinghorn gives away $300m". News Website. Australian Financial Review. Retrieved 23 January 2014.
- "The Kinghorn Foundation - Medical Research". Corporate Website. Kinghorn Foundation. Retrieved 22 January 2014.
- "Australians can map their genomes for $1,000 after institute buys world-first machine". News Website. ABC. Retrieved 25 February 2014.
- Medew, Julia (15 January 2014). "Australian researchers hail new cost-effective gene sequencing machine". Sydney Morning Herald. Retrieved 25 February 2014.
- "Garvan Institute of Medical Research - Breakthrough Research". Corporate Website. Garvan Institute. Retrieved 22 January 2014.
- "Garvan Institute of Medical Research - Governance". Corporate Website. Garvan Institute. Retrieved 22 January 2014.
- "Garvan Institute of Medical Research - About Garvan". Corporate Website. Garvan Institute. Retrieved 10 February 2014.
- "Garvan Institute of Medical Research - About Garvan". Corporate Website. Garvan Institute. Retrieved 10 February 2014.
- "Andrew Giles Talks About Giving to Garvan". YouTube Video. Garvan Institute. Retrieved 24 February 2014.
- "Workplace Giving". Organisation Website. Garvan Institute. Retrieved 24 February 2014.
- "Garvan Institute of Medical Research - History". Corporate Website. Garvan Institute. Retrieved 21 January 2014.
- "Garvan and St Vincent’s to Build $100 million Australian Cancer Centre". Corporate Website. Garvan Institute. Retrieved 21 January 2014.
- Casey, Marcus (30 November 2011). "Cancer survivor Delta Goodrem is ambassador for Kinghorn custom treatment centre in Darlinghurst". The Daily Telegraph. Retrieved 21 January 2014.
- "Tracey Spicer - Biography". Personal Website. Tracey Spicer. Retrieved 21 January 2014.
- "Herald Sun :: Actor Samuel Johnson to unicycle 15,000km to raise $1 million for breast cancer research". News Ltd. 11 January 2013.
- "loveyoursister.org". loveyoursister.org. 2012-2013.
- "Garvan receives $15.5 Million in NHMRC Funding Round". News Story. Garvan Institute. Retrieved 24 February 2014.
- "Garvan Institute of Medical Research - Research Capabilities". Corporate Website. Garvan Institute. Retrieved 23 January 2014.
- "Garvan Attempts DNA World Record". Media Release. Garvan Institute. Retrieved 11 February 2014.
- "Garvan DNA Model Guinness World Record Attempt". YouTube Video. Garvan Institute. Retrieved 11 February 2014.
- Sadler, Denham (14 February 2014). "Samuel Johnson raises $1.5m for breast cancer research in unicycle ride". Sydney Morning Herald. Retrieved 19 February 2014.
- Articles from the Garvan Institute on The Conversation
- Garvan Institute website
- Garvan Institute's YouTube Channel
- The Kinghorn Cancer Centre website
|This article relies on references to primary sources. (July 2007)|