Gastricsin

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Progastricsin (pepsinogen C)
Protein PGC PDB 1avf.png
PDB rendering based on 1avf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PGC ; PEPC; PGII
External IDs OMIM169740 MGI98909 HomoloGene55669 ChEMBL: 2136 GeneCards: PGC Gene
EC number 3.4.23.3
RNA expression pattern
PBB GE PGC 205261 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5225 109820
Ensembl ENSG00000096088 ENSMUSG00000023987
UniProt P20142 Q9D7R7
RefSeq (mRNA) NM_001166424 NM_025973
RefSeq (protein) NP_001159896 NP_080249
Location (UCSC) Chr 6:
41.7 – 41.72 Mb
Chr 17:
47.73 – 47.73 Mb
PubMed search [1] [2]

Gastricsin also known as pepsinogen C is an enzyme that in humans is encoded by the PGC gene.[1][2][3][4]

Function[edit]

Gastricsin is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.[4]

Clinical significance[edit]

Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.[4]

See also[edit]

References[edit]

  1. ^ Hayano T, Sogawa K, Ichihara Y, Fujii-Kuriyama Y, Takahashi K (January 1988). "Primary structure of human pepsinogen C gene". J. Biol. Chem. 263 (3): 1382–5. PMID 3335549. 
  2. ^ Pals G, Azuma T, Mohandas TK, Bell GI, Bacon J, Samloff IM, Walz DA, Barr PJ, Taggart RT (February 1989). "Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter". Genomics 4 (2): 137–48. doi:10.1016/0888-7543(89)90292-9. PMID 2567697. 
  3. ^ Taggart RT, Cass LG, Mohandas TK, Derby P, Barr PJ, Pals G, Bell GI (January 1989). "Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A". J. Biol. Chem. 264 (1): 375–9. PMID 2909526. 
  4. ^ a b c "Entrez Gene: PGC progastricsin (pepsinogen C)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.