|Classification and external resources|
Illustration of a child with gastroschisis
Gastroschisis represents a congenital defect characterized by a defect in the anterior abdominal wall through which the abdominal contents freely protrude. There is no overlying sac and the size of the defect is usually less than 4 centimetres (1.6 in). The abdominal wall defect is located at the junction of the umbilicus and normal skin, and is almost always to the right of the umbilicus.
Widespread use of antenatal ultrasound examination and maternal serum alpha-fetoprotein (MSAFP) screening has made the detection of gastroschisis possible in the second trimester of pregnancy.
Omphalocele is another congenital birth defect, but it involves the umbilical cord itself, and the organs remain enclosed in visceral peritoneum. With omphalocele the defect is usually much larger than in gastroschisis.
High-risk pregnancies such as those complicated by infection, young maternal age, smoking, drug abuse, or anything that contributes to low birth weight can increase the incidence of gastroschisis, which is more frequent in newborns who are small for gestational age. Whether the intrauterine growth retardation can facilitate the apparition of gastroschisis or the abdominal wall defect impairs fetal growth is not clear yet. Numerous clinical studies have linked aspirin, a U.S. Food and Drug Administration (FDA) pregnancy category D drug, as an increased risk factor, and according to large scale study by the California Department of Public Health aspirin quadruples the risk of Gastroschisis.
A change in paternity (childbearing with different fathers) has been implicated as a risk factor in a recent study, suggesting that the immune system of the mother may play a role in the development of gastroschisis.
Gastroschisis as a stand-alone congenital defect, like many birth defects when isolated, exhibits multifactorial determination with a 2-3% recurrence risk for subsequent pregnancies. Rarely, gastroschisis has clustered in families and exhibits autosomal recessive or dominant inheritance. 
Genetic counseling and further genetic testing, such as amniocentesis, may be offered during the pregnancy, as this and other abdominal wall defects are associated with genetic disorders. If there are no additional genetic problems or birth defects, surgery soon after birth can often repair the opening.
At least six hypotheses have been proposed:
- Failure of mesoderm to form in the body wall
- Rupture of the amnion around the umbilical ring with subsequent herniation of bowel
- Abnormal involution of the right umbilical vein leading to weakening of the body wall and gut herniation
- Disruption of the right vitelline (yolk sac) artery with subsequent body wall damage and gut herniation
- Abnormal folding of the body wall results in a ventral body wall defect through which the gut herniates
- Failure to incorporate the yolk sac and related vitelline structures into the yolk sac
The first hypothesis does not explain why the mesoderm defect would occur in such a specific small area. The second hypothesis does not explain the low percentage of associated abnormality compared with omphalocele. The third hypothesis was criticized due to no vascular supplement of anterior abdominal wall by umbilical vein. The fourth hypothesis was commonly accepted, but it was later shown that the right vitelline artery (right omphalomesenteric artery) did not supply the anterior abdominal wall in this area. More evidence is needed to support the fifth hypothesis.
During the fourth week of development, the lateral body folds move ventrally and fuse in the midline to form the anterior body wall. Incomplete fusion results in a defect that allows abdominal viscera to protrude through the abdominal wall. The bowel typically herniates through the rectus muscle, lying to the right of the umbilicus.
The general procedure for gastroschisis is to simply tuck the protruding organs back into the opening and apply a belly band pressure until the wound heals itself. New advances have been pioneered in repairing the protruding bowel by placing a protective "silo" around the intestine outside the abdomen, then slowly pressuring the herniated intestine into the abdominal cavity. This new procedure allows for the bowel to return to its intended shape and location without further traumatizing the infant's viscera with undue internal pressure. The main cause for lengthy recovery periods in patients is the time taken for the infants' bowel function to return to normal.
Current advances in surgical techniques and intensive care management for neonates have increased the survival rate to 90%, in adequate settings. The possibility of prenatal diagnosis either through echosonogram or any other method available allows the mother to be referred to an adequate center where a caesarean section or induced natural birth can be performed before term (as natural birth is recommended and just as safe as with a normal baby), preferably within 2 weeks of term, and allow the immediate surgery to be performed on the newborn.
The morbidity is closely related to the presence of other malformations and complications of the wound or the intestine.
The malformation is slightly more frequent in males than females. The frequency of gastroschisis is associated with young maternal age, low number of gestations, alcohol, tobacco and NSAID use, and infections. This abnormality was historically reported as having a ratio of 1:10,000 and is usually detected before birth. It has been reported that the incidence of gastroschisis has increased in recent years. The CDC currently estimates that about 1,871 babies are born each year in the United States with gastroschisis. 
There is an increased incidence when the mother has a history of cigarette smoking, use of recreational drugs, alcohol consumption, low body mass index, or increased frequency of genitourinary infection.
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- Gastroschisis Diagnosis, Evaluation and Treatment St. Louis Fetal Care Institute
- Fetal Treatment Program - Providence, Rhode Island at Brown University
- Fetal Treatment Center: Gastroschisis at UCSF Medical Center
- Imaging Gastroschisis Ultrasound, MR, CT
- Gastroschisis Evaluation, Repair and Treatment Options Center for Fetal Diagnosis and Treatment at The Children's Hospital of Philadelphia