Gattermann–Koch reaction

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The Gattermann–Koch reaction, named after the German chemists Ludwig Gattermann and Julius Arnold Koch,[1] in organic chemistry refers to a Friedel–Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in situ with Friedel–Crafts catalyst, namely AlCl3 to produce a benzaldehyde derivative from a benzene derivative in one step.[2] Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed along with zinc chloride.


An example would be the conversion of toluene to p-tolualdehyde.[3]

See also[edit]


  1. ^ Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30: 1622. doi:10.1002/cber.18970300288. 
  2. ^ LI Jie Jack (2003). Name Reactions: A Collection of Detailed Reaction Mechanisms (available on Google Books) (2nd ed.). Springer. p. 157. ISBN 3-540-40203-9. 
  3. ^ G. H. Coleman, David Craig (1943), "p-Tolualdehyde", Org. Synth. ; Coll. Vol. 2: 583