Gattermann–Koch reaction

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The Gattermann–Koch reaction, named after the German chemists Ludwig Gattermann and Julius Arnold Koch,[1] in organic chemistry refers to a Friedel–Crafts acylation reaction in which carbon monoxide and hydrochloric acid are used in situ with Friedel–Crafts catalyst, namely AlCl3 to produce a benzaldehyde derivative from a benzene derivative in one step.[2] Benzaldehyde and many aromatic aldehydes are conveniently synthesized by this reaction. Presence of traces of copper(I) chloride are also needed along with zinc chloride.

Gattermann-Koch.svg

An example would be the conversion of toluene to p-tolualdehyde.[3]

See also[edit]

References[edit]

  1. ^ Gattermann, L.; Koch, J. A. (1897). "Eine Synthese aromatischer Aldehyde". Ber. 30: 1622. doi:10.1002/cber.18970300288. 
  2. ^ LI Jie Jack (2003). Name Reactions: A Collection of Detailed Reaction Mechanisms (available on Google Books) (2nd ed.). Springer. p. 157. ISBN 3-540-40203-9. 
  3. ^ G. H. Coleman, David Craig (1943), "p-Tolualdehyde", Org. Synth. ; Coll. Vol. 2: 583