Location in Cherokee County and the state of Alabama
|• Total||0.3 sq mi (0.9 km2)|
|• Land||0.3 sq mi (0.9 km2)|
|• Water||0 sq mi (0 km2)|
|Elevation||594 ft (181 m)|
|• Density||466.7/sq mi (155.6/km2)|
|Time zone||Central (CST) (UTC-6)|
|• Summer (DST)||CDT (UTC-5)|
|GNIS feature ID||0118879|
Gaylesville is named for George W. Gayle, an Alabama politician.
Gaylesville is located at 34°16'4.778" North, 85°33'29.678" West (34.267994, -85.558244).
According to the U.S. Census Bureau, the town has a total area of 0.3 square miles (0.78 km2), of which, 0.3 square miles (0.78 km2) of it is land and none of it is covered by water.
As of the census of 2000, there were 140 people, 61 households, and 45 families residing in the town. The population density was 403.0 people per square mile (154.4/km²). There were 65 housing units at an average density of 187.1 per square mile (71.7/km²). The racial makeup of the town was 99.29% White, 0.00% Black or African American, 0.00% Native American, 0.00% Asian, 0.00% Pacific Islander, 0.00% from other races, and 0.71% from two or more races. 0.00% of the population were Hispanic or Latino of any race.
There were 61 households out of which 21.3% had children under the age of 18 living with them, 59.0% were married couples living together, 11.5% had a female householder with no husband present, and 26.2% were non-families. 24.6% of all households were made up of individuals and 13.1% had someone living alone who was 65 years of age or older. The average household size was 2.30 and the average family size was 2.71.
In the town the population was spread out with 16.4% under the age of 18, 6.4% from 18 to 24, 33.6% from 25 to 44, 31.4% from 45 to 64, and 12.1% who are 65 years of age or older. The median age was 43 years. For every 100 females there were 97.2 males. For every 100 females age 18 and over, there were 98.3 males.
The median income for a household in the town was $26,875, and the median income for a family was $33,750. Males had a median income of $32,813 versus $20,313 for females. The per capita income for the town was $13,531. 13.0% of the population and 12.2% of families were below the poverty line. Out of the total people living in poverty, 10.7% were under the age of 18 and 10.5% were 65 or older.
Gaylesville is served by Gaylesville School (PK-12), home of the Trojans, which is a member of the Cherokee County School System.
Gaylesville Public Schools are part of the Cherokee County School District. Schools in the district include Cedar Bluff School, Centre Elementary School, Gaylesville School, Sand Rock School, Centre Middle School, Cherokee County High School, Spring Garden High School and Cherokee County Career & Technology Center.
Mitchell Guice is the Superintendent of Schools. 
- Gannett, Henry (1905). The Origin of Certain Place Names in the United States. Govt. Print. Off. p. 135.
- "US Gazetteer files: 2010, 2000, and 1990". United States Census Bureau. 2011-02-12. Retrieved 2011-04-23.
- "American FactFinder". United States Census Bureau. Retrieved 2008-01-31.
- "Cherokee County Schools". Cherokee County Schools. Retrieved 2012-06-21.