Gemazocine

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Gemazocine
Gemazocine structure.svg
Systematic (IUPAC) name
10-(cyclopropylmethyl)-1-ethyl-13,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2,4,6-trien-4-ol
Clinical data
Legal status
?
Identifiers
CAS number 54063-47-7
ATC code None
PubChem CID 219096
ChemSpider 189916
Chemical data
Formula C20H29NO 
Mol. mass 299.450 g/mol

Gemazocine (R-15,497), also known as cyclogemine, is a non-selective opioid antagonist of the benzomorphan class.[1][2][3] It may have partial agonist properties at some of the opioid receptors, such as at the kappa receptor (as it induces dysphoric effects in humans), but seems to be generally antagonistic in its actions.[4]

References[edit]

  1. ^ Macdonald, F. (1997). Dictionary of Pharmacological Agents. CRC Press. p. 955. ISBN 978-0-412-46630-4. Retrieved 22 April 2012. 
  2. ^ Gelders, Y. G.; de Ranter, C. J.; Schenk, H. (1979). "Structural Studies of Substituted 6,7-Benzomorphan Compounds. I. The Absolute Configuration of (−)-2-Cyclopropylmethyl-2'-hydroxy-5-ethyl-9,9-dimethyl-6,7-benzomorphan (Gemazocine) Hydrobromide". Acta Crystallographica B 35 (3): 699–703. doi:10.1107/S0567740879004477. 
  3. ^ Verlinde C, De Ranter C (August 1988). "Assessment of the kappa-opioid activity of a series of 6,7-benzomorphans in the rabbit vas deferens". Eur. J. Pharmacol. 153 (1): 83–7. PMID 2850928. 
  4. ^ Freye, E.; Hartung, E.; Schenk, G. K. (1983). "Bremazocine: An Opiate That Induces Sedation and Analgesia without Respiratory Depression" (pdf). Anesthesia and Analgesia 62 (5): 483–488. doi:10.1213/00000539-198305000-00005. PMID 6301311.