Gene redundancy
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(Redirected from Gene Redundancy)
Gene redundancy is the existence of several genes in the genome of an organism that perform the same role to some extent. This is the case for many sets of paralogous genes. When an individual gene in such a set is disrupted by mutation or targeted knockout, there can be little effect on phenotype as a result of gene redundancy, whereas the effect is large for double or triple gene knockouts.[1]
[edit] References
- ^ Pérez-Pérez JM, Candela H, Micol JL (August 2009). "Understanding synergy in genetic interactions". Trends Genet. 25 (8): 368–76. doi:10.1016/j.tig.2009.06.004. PMID 19665253.
[edit] Further reading
- Lehner B (2007). "Modelling genotype-phenotype relationships and human disease with genetic interaction networks". J Exp Biol 210 (9): 1559–66. doi:10.1242/jeb.002311. PMID 17449820. http://jeb.biologists.org/cgi/content/full/210/9/1559.
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