Project goals and scope
Number of gene articles
The human genome contains an estimated 20,000–25,000 protein-coding genes. The goal of the Gene Wiki project is to create seed articles for every notable human gene, that is, every gene whose function has been assigned in the peer-reviewed scientific literature. Approximately half of human genes have assigned function, therefore the total number of articles seeded by the Gene Wiki project would be expected to be in the range of 10,000 - 15,000. To date, approximately 10,271 articles have been created or augmented to include Gene Wiki project content.
Once seed articles have been established, the hope and expectation is that these will be annotated and expanded by editors ranging in experience from the lay audience to students to professionals and academics.
Proteins encoded by genes
The majority of genes encode proteins hence understanding the function of a gene generally requires understanding of the function of the corresponding protein. In addition to including basic information about the gene, the project therefore also includes information about the protein encoded by the gene.
Gene Wiki generated content
Stubs for the Gene Wiki project are created by a bot and contain links to the following primary gene/protein databases:
- HUGO Gene Nomenclature Committee – official gene name
- Entrez – Gene database
- OMIM (Mendelian Inheritance in Man) – database that catalogues all the known diseases with a genetic component
- Amigo – Gene Ontology
- HomoloGene – gene homologs in other species
- SymAtlasRNA – gene expression pattern in tissues
- Protein Data Bank – 3D structure of protein encoded by the gene
- UniProt (universal protein resource) – a central repository of protein data
- Portal:Gene Wiki/Other Wikis – a list of Gene Wikis external to Wikipedia
- Huss JW, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI (July 2008). "A Gene Wiki for Community Annotation of Gene Function". PLoS Biol. 6 (7): e175. doi:10.1371/journal.pbio.0060175. PMC 2443188. PMID 18613750.
- Huss JW, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI. "SciVee Pubcast: A Gene Wiki for Community Annotation of Gene Function". Retrieved 2008-11-19.
- Huss JW; Lindenbaum P; Martone M et al. (January 2010). "The Gene Wiki: community intelligence applied to human gene annotation". Nucleic Acids Res. 38 (Database issue): D633–9. doi:10.1093/nar/gkp760. PMC 2808918. PMID 19755503.
- Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES (December 2007). "Distinguishing protein-coding and noncoding genes in the human genome". Proc. Natl. Acad. Sci. U.S.A. 104 (49): 19428–33. doi:10.1073/pnas.0709013104. PMC 2148306. PMID 18040051.
- "Gene Wiki Pages". Pages that link to Template:PBB Controls. Wikipedia, the free encyclopedia. Retrieved 2008-07-19.
- Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6062–7. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.
- Spagat E (2008-07-09). ": Edit your DNA: `Gene wiki' to debut on Wikipedia". The Associated Press (in ABC News. Retrieved 2011-09-29.
- McKenney AS (2008-07-08). "Archiving Information About The Human Genome Using Wikipedia". IT / Internet / E-mail News. Medical News Today. Retrieved 2008-07-19.
- Tay L (2008-07-10). "Wikipedia hosts human gene repository". iTnews Australia. Haymarket Media. Retrieved 2008-07-19.
- Mitch Waldrop (3 September 2008). "Big data: Wikiomics". Nature. pp. 22–25.
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