|Section of vesicular ovarian follicle of cat. X 50. (Discus proligerus labeled at lower left.)|
|Gray's||subject #266 1256|
The cumulus oophorus (Latin cumulus=heap, Greek oo=egg + phor=carrier; latinized ending "-us"), also called discus proligerus, is a cluster of cells (called cumulus cells) that surround the oocyte both in the ovarian follicle and after ovulation. In the antral follicle, it may be regarded as an extension of the membrana granulosa. The innermost layer of these cells is the corona radiata.
This layer of cells must be penetrated by the spermatozoa in order for fertilization to occur.
Functions of the cumulus oophorus include coordination of follicular development and oocyte maturation. Mechanisms of the latter include stimulation of amino acid transport and sterol biosynthesis and regulation of oocyte gene transcription.
It also provides energy substrates for oocyte meiotic resumption and promotes glycolysis.
In addition, it provides protection for the oocyte.
Gene expression profiling 
As a part of the process of in vitro fertilization, gene expression profiling of cumulus cells can be performed to estimate oocyte quality and the efficiency of an ovarian hyperstimulation protocol, and may indirectly predict oocyte aneuploidy, embryo development and pregnancy outcomes. Increased knowledge in these aspects is useful in, for example, embryo selection.
In contrast, genes where increased expression is correlated with lower oocyte competence or worse pregnancy outcomes include: BDNF, CCND2, CXCR4, GPX3, HSPB1, DVL3, DHCR7, CTNND1, TRIM28, STAR, AREG, CX43, PTGS2, SCD1 and SCD5.
- Gilbert, Scott F. Developmental Biology (Ninth ed.). Sinauer Associates, Inc. p. 126. ISBN 0878933840.
- Fauser, B. C. J. M.; Diedrich, K.; Bouchard, P.; Dominguez, F.; Matzuk, M.; Franks, S.; Hamamah, S.; Simon, C. et al. (2011). "Contemporary genetic technologies and female reproduction". Human Reproduction Update 17 (6): 829–847. doi:10.1093/humupd/dmr033. PMC 3191938. PMID 21896560.
- Organology at UC Davis Reproductive/mammal/ovary5/ovary3 - "Mammal, bovine ovary (LM, Medium)"
- Anatomy at MUN repro/reproov
- Swiss embryology (from UL, UB, and UF) dbefruchtung/objectbefru01
- UIUC Histology Subject 366
- BU Histology Learning System: 18404loa - "Female Reproductive System: ovary, cumulus oophorus"
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