In April 2001, Via Health, the company that owned the hospital, announced that the hospital would close within 90 days in an effort to cut costs. The move was met with criticism from community members and workers at the hospital.
The hospital site and buildings remained intact after the hospital's closure, and ViaHealth retained a presence, with a diabetes center and some other facilities. In April 2006, Buckingham Properties purchased the site, and in February 2007, announced that the property would be transformed into a mixed-use site, with apartments, offices and retail space. 
- "The History of the Genesee Hospital". ViaHealth. Retrieved 2007-11-09.
- Gene Clancy (April 26, 2001). "'Save Genesee Hospital' campaign builds momentum". Workers World Party. Retrieved 2007-11-09.
- Mary Chao (February 7, 2007). "Retail, apartments, offices planned for former Genesee Hospital site". Rochester Democrat and Chronicle. Retrieved 2014-11-04.
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