Genetic history of the Turkish people

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In population genetics the question has been debated whether the modern Turkish population is significantly related to other Turkic peoples, or whether they are rather derived from indigenous populations of Anatolia which were culturally assimilated during the Middle Ages. The contribution of the Central Asian genetics to the modern Turkish people has been debated and become the subject of several studies. As a result, several studies have concluded that the indigenous peoples of Anatolia are the primary source of the present-day Turkish population,[1][2][3][4][5][6][7] in addition to contributions from neighboring peoples,[2] from the Caucasus, Balkans, and the Near East,[8] with a small contribution from Central Asia and East Asia.[2]

Central Asian and Uralic connection[edit]

The question to what extent a gene flow from Central Asia to Anatolia has contributed to the current gene pool of the Turkish people, and what the role is in this of the 11th century settlement by Oghuz Turks, has been the subject of several studies. A factor that makes it difficult to give reliable estimates, is the problem of distinguishing between the effects of different migratory episodes. Several studies have concluded that the historical and indigenous Anatolian groups are the primary source of the present-day Turkish population.[1][2][3][4][5][6][7] Thus, although the Turks settled in Anatolia (peacefully or after war events) with cultural significance, including the introduction of the Turkish language and Islam, the genetic significance from Central Asia might have been slight.[3][9][10]

Some of the Turkic peoples originated from Central Asia and therefore are possibly related with Xiongnu.[11] A majority (89%) of the Xiongnu sequences can be classified as belonging to Asian haplogroups and nearly 11% belong to European haplogroups.[11] This finding indicates that the contacts between European and Asian populations were anterior to the Xiongnu culture,[11] and it confirms results reported for two samples from an early 3rd century B.C. Scytho-Siberian population.[12]

According to another archeological and genetic study in 2010, the paternal Y-chromosome R1a, which is considered as an Indo-European marker, was found in three skeletons in 2000-year-old elite Xiongnu cemetery in Northeast Asia, which would support Kurgan expansion hypothesis for the Indo-European expansion from the Volga steppe region,[13] even though, genealogical DNA analysis indicates a migration of R1a peoples eastward from Europe to the Russian Plain between 4800 and 4600 years before present, a direction opposite to that suggested by the Kurgan theory. As the R1a was found in Xiongnu people[14] and the present-day people of Central Asia[15] Analysis of skeletal remains from sites attributed to the Xiongnu provides an identification of dolichocephalic Mongoloid, ethnically distinct from neighboring populations in present-day Mongolia.[16]

According to a different genetic research on 75 individuals from various parts of Turkey, Mergen et al. revealed that genetic structure of the mtDNAs in the Turkish population bears similarities to Turkic Central Asian populations. The neighbour-joining tree built from segment I sequences for Turkish and the other populations (French, Bulgarian, British, Finnish, Greek, German, Kazakhs, Uighurs and Kirghiz) indicated two poles. Turkic Central Asian populations, Turkish population and British population formed one pole, and European populations formed the other, which revealed Turkish population bears more similarities to Turkic Central Asian population and British people.[17]

Overall, modern Turks are most related to neighbouring West Asian populations. A study looking into allele frequencies suggested that there was a lack of genetic relationship between contemporary Mongols and Turks, despite their linguistic and cultural relationship.[18] In addition, another study looking into HLA genes allele distributions indicated that Anatolians did not significantly differ from other Mediterranean populations.[10] Multiple studies suggested an elite dominance-driven linguistic replacement model to explain the adoption of Turkish language by Anatolian indigenous inhabitants.[1][7]

Haplogroup distributions in Turkish people[edit]

Y chromosome Haplogroup distribution of Turkish people.[5]

According to Cinnioglu et al., (2004)[19] there are many Y-DNA haplogroups present in Turkey. The majority haplogroups are shared with their "West Asian" and "Caucasian' neighbours. By contrast, "Central Asian" haplogroups are rarer, N and Q)- 5.7% (but it rises to 36% if K, R1a, R1b and L- which infrequently occur in Central Asia, but are notable in many other Western Turkic groups), India H, R2 - 1.5% and Africa A, E3*, E3a - 1%.

Some of the percentages identified were:[5]

  • J2=24% - J2 (M172)[5] Typical of Mediterranean, Caucasian, Western and Central Asian populations.[20]
  • R1b=14.7%[5] Widespread in western Eurasia, with distinct 'west Asian' and 'west European' lineages. The predominant haplogroup among Armenians.
  • G=10.9%[5] - Typical of people from the Caucasus and to a lesser extent the Middle East.
  • E3b-M35=10.7%[5] (E3b1-M78 and E3b3-M123 accounting for all E representatives in the sample, besides a single E3b2-M81 chromosome). E-M78 occurs commonly, and is found in northern and eastern Africa, western Asia[21] Haplogroup E-M123 is found in both Africa and Eurasia.
  • J1=9%[5] - Typical amongst people from the Arabian Peninsula and Dagestan (ranging from 3% from Turks around Konya to 12% in Kurds).
  • R1a=6.9%[5] - Common in various Central Asian, Indian, and Eastern European populations.
  • I=5.3%[5] - Common in Balkans and eastern Europe, possibly representing a back-migration to Anatolia.
  • K=4.5%[5] - Typical of Asian populations and Caucasian populations.
  • L=4.2%[5] - Typical of Indian Subcontinent and Khorasan populations. Found sporadically in the Middle East and the Caucasus.
  • N=3.8%[5] - Typical of Uralic, Siberian and Altaic populations.
  • T=2.5%[5] - Typical of Mediterranean, Middle Eastern, Northeast African and South Asian populations
  • Q=1.9%[5] - Typical of Northern Altaic populations.

Further research on Turkish Y-DNA groups[edit]

A study from Turkey by Gokcumen (2008)[22][23] took into account oral histories and historical records. They went to four settlements in Central Anatolia and did not do a random selection from a group of university students like many other studies. Accordingly here are the results:

1) At an Afshar village whose oral stories tell they come from Central Asia they found that 57% come from haplogroup L, 13% from haplogroup Q, 3% from haplogroup N thus indicating that the L haplogroups in Turkey are of Central Asian heritage rather than Indian, although these Central Asians would have gotten the L markers from the Indians from the beginning. These Asian groups add up to 73% in this village. Furthermore 10% of these Afshars were E3a and E3b. Only 13% were J2a, the most common haplogroup in Turkey.

2) An older Turkish village center that did not receive much migration was about 25% N and 25% J2a with 3% G and close to 30% of some sort of R1 but mostly R1b.

Other studies[edit]

Genetic affinities among Southeastern European and Central Asian populations.[24]

In 2001, Benedetto et al. revealed that Central Asian genetic contribution to the current Anatolian mtDNA gene pool was estimated as roughly 30%, by comparing the populations of Mediterranean Europe, and Turkic-speaking people of Central Asia.[25] In 2003, Cinnioğlu et al. made a research of Y-DNA including the samples from eight regions of Turkey, without classifying the ethnicity of the people, which indicated that high resolution SNP analysis totally provides evidence of a detectable weak signal (<9%) of gene flow from Central Asia.[5] It was observed that the male contribution from Central Asia to Turkish population with reference to the Balkans was 13%.[26] In 2006, Berkman concluded that the true Central Asian contribution to Anatolia for both males and females were assumed to be 22%, with respect to the Balkans.[27]

In 2011 Aram Yardumian and Theodore G. Schurr published their study "Who Are the Anatolian Turks? A Reappraisal of the Anthropological Genetic Evidence." They revealed the impossibility of long-term, and continuing genetic contacts between Anatolia and Siberia, and confirmed the presence of significant mitochondrial DNA and Y-chromosome divergence between these regions, with minimal admixture. The research confirms also the lack of mass migration and suggested that it was irregular punctuated migration events that engendered large-scale shifts in language and culture among Anatolia's diverse autochthonous inhabitants.[1]

According to a 2012 study on ethnic Turkish people, "Turkish population has a close genetic similarity to Middle Eastern and European populations and some degree of similarity to South Asian and Central Asian populations."[2] At K = 3 level, using individuals from the Middle East (Druze and Palestinian), Europe (French, Italian, Tuscan and Sardinian) and Central Asia (Uygur, Hazara and Kyrgyz), clustering results indicated that the contributions were 45%, 40% and 15% for the Middle Eastern, European and Central Asian populations, respectively. For K = 4 level, results were 38% European, 35% Middle Eastern, 18% South Asian and 9% Central Asian. However, Hodoglugil et al. caution that results may indicate previous population movements (e.g. migration, admixture) or genetic drift, given Europe and South Asia have some genetic relatedness.[2] The study indicated that the Turkish genetic structure is unique, and admixture of Turkish people reflects the population migration patterns.[2] Among all sampled groups, the Adygei population from the Caucasus was closest to the Turkish samples.[2]

A group of Armenian scientists conducted a study about the origins of the Turkish people in relation to Armenians. Savak Avagian; director of Armenia's bone marrow bank found that “Turks and Armenians were the two societies throughout the world that were genetically close to each other. Kurds are also in same genetic pool”.[28]

Another studies found the Peoples of the Caucasus (Georgians, Circassians, Armenians) are closest to the Turkish population among sampled European (French, Italian), Middle Eastern (Druze, Palestinian), and Central (Kyrgyz, Hazara, Uygur), South (Pakistani), and East Asian (Mongolian, Han) populations.[2][29][30][31][32][33]

See also[edit]

References and notes[edit]

  1. ^ a b c d Yardumian, A.; Yardumian, T. G. (2011). "Who Are the Anatolian Turks?". Anthropology & Archeology of Eurasia 50: 6–42. doi:10.2753/AAE1061-1959500101.  edit
  2. ^ a b c d e f g h i Hodoğlugil, U. U.; Mahley, R. W. (2012). "Turkish Population Structure and Genetic Ancestry Reveal Relatedness among Eurasian Populations". Annals of Human Genetics 76 (2): 128–141. doi:10.1111/j.1469-1809.2011.00701.x. PMID 22332727.  edit
  3. ^ a b c Rosser, Z.; Zerjal, T.; Hurles, M.; Adojaan, M.; Alavantic, D.; Amorim, A.; Amos, W.; Armenteros, M.; Arroyo, E.; Barbujani, G.; Beckman, G.; Beckman, L.; Bertranpetit, J.; Bosch, E.; Bradley, D. G.; Brede, G.; Cooper, G.; Côrte-Real, H. B.; De Knijff, P.; Decorte, R.; Dubrova, Y. E.; Evgrafov, O.; Gilissen, A.; Glisic, S.; Gölge, M.; Hill, E. W.; Jeziorowska, A.; Kalaydjieva, L.; Kayser, M.; Kivisild, T. (2000). "Y-Chromosomal Diversity in Europe is Clinal and Influenced Primarily by Geography, Rather than by Language". The American Journal of Human Genetics 67 (6): 1526–1543. doi:10.1086/316890. PMC 1287948. PMID 11078479.  edit[1]
  4. ^ a b Nasidze I, Sarkisian T, Kerimov A, Stoneking M (March 2003). "Testing hypotheses of language replacement in the Caucasus: evidence from the Y-chromosome". Hum. Genet. 112 (3): 255–61. doi:10.1007/s00439-002-0874-4. PMID 12596050. [2]
  5. ^ a b c d e f g h i j k l m n o p q Cinnioglu, C.; King, R.; Kivisild, T.; Kalfoğlu, E.; Atasoy, S.; Cavalleri, G. L.; Lillie, A. S.; Roseman, C. C.; Lin, A. A.; Prince, K.; Oefner, P. J.; Shen, P.; Semino, O.; Cavalli-Sforza, L. L.; Underhill, P. A. (2004). "Excavating Y-chromosome haplotype strata in Anatolia". Human Genetics 114 (2): 127–148. doi:10.1007/s00439-003-1031-4. PMID 14586639.  edit[3]
  6. ^ a b Arnaiz-Villena, A.; Karin, M.; Bendikuze, N.; Gomez-Casado, E.; Moscoso, J.; Silvera, C.; Oguz, F. S.; Sarper Diler, A.; De Pacho, A.; Allende, L.; Guillen, J.; Martinez Laso, J. (2001). "HLA alleles and haplotypes in the Turkish population: Relatedness to Kurds, Armenians and other Mediterraneans". Tissue Antigens 57 (4): 308–317. doi:10.1034/j.1399-0039.2001.057004308.x. PMID 11380939.  edit
  7. ^ a b c Wells, R. S.; Yuldasheva, N.; Ruzibakiev, R.; Underhill, P. A.; Evseeva, I.; Blue-Smith, J.; Jin, L.; Su, B.; Pitchappan, R.; Shanmugalakshmi, S.; Balakrishnan, K.; Read, M.; Pearson, N. M.; Zerjal, T.; Webster, M. T.; Zholoshvili, I.; Jamarjashvili, E.; Gambarov, S.; Nikbin, B.; Dostiev, A.; Aknazarov, O.; Zalloua, P.; Tsoy, I.; Kitaev, M.; Mirrakhimov, M.; Chariev, A.; Bodmer, W. F. (2001). "The Eurasian Heartland: A continental perspective on Y-chromosome diversity". Proceedings of the National Academy of Sciences 98 (18): 10244–10249. doi:10.1073/pnas.171305098. PMC 56946. PMID 11526236.  edit
  8. ^ Comas, D.; Schmid, H.; Braeuer, S.; Flaiz, C.; Busquets, A.; Calafell, F.; Bertranpetit, J.; Scheil, H. -G.; Huckenbeck, W.; Efremovska, L.; Schmidt, H. (2004). "Alu insertion polymorphisms in the Balkans and the origins of the Aromuns". Annals of Human Genetics 68 (2): 120–127. doi:10.1046/j.1529-8817.2003.00080.x. PMID 15008791.  edit
  9. ^ Mergen et al. Mitochondrial DNA sequence variation in the Anatolian Peninsula (Turkey), Journal of Genetics, Vol. 83, No.1, April 2004, P.46, Figure 4. http://www.ias.ac.in/jgenet/Vol83No1/39.pdf & http://www.ncbi.nlm.nih.gov/pubmed/15240908
  10. ^ a b Tissue Antigens Volume 60 Issue 2 Page 111-121, August(2002) Population genetic relationships between Mediterranean populations determined by HLA allele distribution and a historic perspective. Tissue Antigens 60 (2), 111–121
  11. ^ a b c Christine Keyser-Tracqui, Eric Crubézy, Bertrand Ludes, Nuclear and Mitochondrial DNA Analysis of a 2,000-Year-Old Necropolis in the Egyin Gol Valley of Mongolia, The American Journal of Human Genetics, Volume 73, Issue 2, August 2003, Pages 247-260, ISSN 0002-9297, 10.1086/377005
  12. ^ Clisson, I.; Keyser, C.; Francfort, H. P.; Crubezy, E.; Samashev, Z.; Ludes, B. (2002). "Genetic analysis of human remains from a double inhumation in a frozen kurgan in Kazakhstan". International Journal of Legal Medicine 116 (5): 304–308. doi:10.1007/s00414-002-0295-x. PMID 12376844. 
  13. ^ Kim et al. A western Eurasian male is found in 2000-year-old elite Xiongnu cemetery in Northeast Mongolia, Am J Phys Anthropol. 2010 Jul;142(3):429-40, quoted pg.2 "The Kurgan expansion hypothesis explains the IndoEuropean expansion from the Volga steppe region (Gimbutas, 1973; Mallory, 1989).The paternal Y-chromosome single nucleotide polymorphisms (Y-SNP) R1a1 is considered as an Indo-European marker, supporting Kurgan expansion hypothesis (Zerjal et al., 1999; Kharkov et al., 2004; Haak et al., 2008). Recent finding of R1a1 in the Krasnoyarsk area east of Siberia marks the eastward expansion of the early Indo-Europeans (Keyser-Tracqui et al., 2009). R1a1 was not found in Scytho-Siberian skeletons from the Seby¨stei site of Altai Republic or in Xiongnu skeletons from Egyin Gol of Mongolia (KeyserTracqui et al., 2009)." quoted p.10: ", paternal, maternal, and biparental genetic analyses were done on three Xiongnu tombs of Northeast Mongolia 2,000 years ago. We showed for the first time that an Indo-European with paternal R1a1 and maternal U2e1 was present in the Xiongnu Empire of ancient Mongolia"
  14. ^ Kim et al. A western Eurasian male is found in 2000-year-old elite Xiongnu cemetery in Northeast Mongolia, Am J Phys Anthropol. 2010 Jul;142(3):429-40
  15. ^ Xue et al. Male Demography in East Asia: A North–South Contrast in Human Population Expansion Times, Genetics. 2006April; 172(4): 2431–2439. doi: 10.1534/genetics.105.054270
  16. ^ Fu ren da xue (Beijing, China), S.V.D. Research Institute, Society of the Divine Word - 2003 [4]
  17. ^ Hatice Mergen et al. Mitochondrial DNA sequence variation in the Anatolian Peninsula (Turkey), Journal of Genetics, Vol. 83, No.1, April 2004, article p.46 and fig.4 Online Read or http://www.ncbi.nlm.nih.gov/pubmed/15240908
  18. ^ Tissue Antigens. Volume 61 Issue 4 Page 292–299, April 2003. Genetic affinities among Mongol ethnic groups and their relationship to Turks
  19. ^ Excavating Y-chromosome haplotype strata in Anatolia. Hum Genet (2004) 114 : 127–148, Springer-Verlag 2003
  20. ^ Journal of Human Genetics (2010) 55, 314–322; doi:10.1038/jhg.2010.30; published online 23 April 2010, Link. Quote: "The J2-M172 lineages likely entered China during the eastward migration of Central Asians."
  21. ^ Cruciani, F.; La Fratta, R.; Torroni, A.; Underhill, P. A.; Scozzari, R. (2006). "Molecular dissection of the Y chromosome haplogroup E-M78 (E3b1a): A posteriori evaluation of a microsatellite-network-based approach through six new biallelic markers". Human Mutation 27 (8): 831–2. doi:10.1002/humu.9445. PMID 16835895.  edit
  22. ^ Gokcumen O. et al (2008), Ethnohistorical and genetic survey of four Central Anatolian settlements, a dissertation/thesis
  23. ^ Gokcumen O. Ethnohistorical and genetic survey of four central Anatolian settlements, dissertation, Univ. of Pennsylvania, 2008.
  24. ^ Varzari et al. (2007) Population history of the Dniester-Carpathians: evidence from Alu markers. J Hum Genet. 2007;52(4):308-16. [5]
  25. ^ Online Reference Di Benedetto G, Ergüven A, Stenico M, Castrì L, Bertorelle G, Togan I, Barbujani G., DNA diversity and population admixture in Anatolia, Am J Phys Anthropol. 115(2):144-56, 2001. quoted: "The Turkic language was introduced in Anatolia at the start of this millennium, by nomadic Turkmen groups from Central Asia. Whether that cultural transition also had significant population-genetics consequences is not fully understood. Three nuclear microsatellite loci, the hypervariable region I of the mitochondrial genome, six microsatellite loci of the Y chromosome, and one Alu insertion (YAP) were amplified and typed in 118 individuals from four populations of Anatolia. For each locus, the number of chromosomes considered varied between 51-200. Genetic variation was large within samples, and much less so between them. The contribution of Central Asian genes to the current Anatolian gene pool was quantified using three different methods, considering for comparison populations of Mediterranean Europe, and Turkic-speaking populations of Central Asia. The most reliable estimates suggest roughly 30% Central Asian admixture for both mitochondrial and Y-chromosome loci. That (admittedly approximate) figure is compatible both with a substantial immigration accompanying the arrival of the Turkmen armies (which is not historically documented), and with continuous gene flow from Asia into Anatolia, at a rate of 1% for 40 generations. Because a military invasion is expected to more deeply affect the male gene pool, similar estimates of admixture for female- and male-transmitted traits are easier to reconcile with continuous migratory contacts between Anatolia and its Asian neighbors, perhaps facilitated by the disappearance of a linguistic barrier between them." [http://www.ncbi.nlm.nih.gov/pubmed/11385601 Online Reference
  26. ^ The Asian contribution to the Turkish population with respect to the Balkans: Y-chromosome perspective[6]
  27. ^ Ceren Berkman, Comparative Analyses for the Central Asian Contribution to Anatolian Gene Pool with Reference to Balkans, p.98, METU, Sep. 2006 quoted "Lower male than female contribution from Central Asia to Anatolia was obtained. The situation was explained by invoking the idea of homogenization between the males of the Balkans and Anatolia. Since females could not migrate alone, the true Central Asian contribution for both males and females were assumed to be 22%."
  28. ^ Cansu ÇAMLIBEL (December 24, 2009). "Turks, Armenians share similar genes, say scientists". Hurriyet Daily News. Retrieved 7 May 2013. 
  29. ^ http://1.bp.blogspot.com/-iYKtdl7HCQY/Tcl1NyLeNnI/AAAAAAAADsI/dYqMpnclWt4/s1600/1_2.png
  30. ^ http://1.bp.blogspot.com/-UCP5T1pduGU/TzpBa9QbK3I/AAAAAAAAEe4/_uWuqnnb1zQ/s1600/1_2.png
  31. ^ http://img6.imageshack.us/img6/7793/fairyprincesspca.png
  32. ^ http://www.nature.com/nature/journal/v466/n7303/images/nature09103-f2.2.jpg
  33. ^ http://4.bp.blogspot.com/_Ish7688voT0/TPBJmmJLScI/AAAAAAAAC7Y/RezgY2l49Vg/s1600/ADMIXTURE_10.png