Geoffrey M. Cooper

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Geoffrey M. Cooper is associate dean of the natural sciences and professor of biology at Boston University. He earned his Ph.D. at the University of Miami in 1973 and was a postdoctoral fellow with nobel laureate Howard Temin. His work includes cellular growth control, cancer, and signal transduction. More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control proliferation, differentiation, and survival of mammalian cells."[1] He is also the author of the popular textbook "The Cell".


  • Terragni J, Nayak G, Banerjee S, Medrano JL, Graham JR, Brennan JF, Sepulveda S, Cooper GM. 2011. The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling. J Biol Chem. Oct 21;286(42):36215-27.
  • Terragni J*, Graham JR*, Adams KW, Schaffer ME, Tullai JW, Cooper GM. 2008. Phosphatidylinositol 3-kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non-canonical activation of NFkappaB transcription factors. BMC Cell Biol. Jan 28;9:6
  • Tullai JW, Schaffer ME, Mullenbrock S, Sholder G, Kasif S, Cooper GM. 2007. Immediate-early and delayed primary response genes are distinct in function and genomic architecture. J Biol Chem. Aug 17;282(33):23981-95.
  • Adams, K.W., and Cooper, G.M. 2007. Rapid turnover of Mcl-1 couples translation to cell survival and apoptosis. J. Biol. Chem. 282:6192-6200.
  • Tullai, J.W., Chen, J., Schaffer, M.E., Kamenetsky, E., Kasif, S. and Cooper, G.M. 2007. GSK-3b mediates repression of CREB target genes in quiescent cells. J. Biol. Chem. 282:9482-9491.
  • Cooper, G.M. and Hausman, R. E. 2006. The Cell: A Molecular Approach 4th ed. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
  • Gross, V.S., Hess, M., and Cooper, G.M. 2005. Mouse embryonic stem cells and preimplantation embryos require signaling through the phosphatidylinositol 3-kinase pathway to suppress apoptosis. Mol. Reprod. Dev. 70:324-332.
  • Zilz, A. and Cooper, G.M. 2004. A binding site for germ cell nuclear factor within the c-mos regulatory sequences. Mol. Reprod. Dev. 67:55-64.
  • Tullai, J.W., Schaffer, M.E., Mullenbrock, S., Kasif, S., and Cooper, G.M. 2004. Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and MEK/ERK signaling pathways. J. Biol. Chem. 279: 20167-20177.
  • Pagon, Z., Volker, J., Cooper, G.M., and Hansen, U. 2003. Mammalian transcription factor LSF is a target of ERK signaling. J. Cell. Biochem. 89:733-746.
  • Cooper, G.M. and Hausman, R.E. 2003. The Cell: A Molecular Approach 3rd ed. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
  • Hartley, D. and Cooper, G.M. 2002. The role of mTOR in the degradation of IRS-1: regulation of PP2A activity. J. Cell. Biochem. 85:304-314.
  • Pap, M., and Cooper, G.M. 2002. Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3b pathway. Mol. Cell. Biol. 22:578-586.
  • Cooper, G.M. 2000. The Cell: A Molecular Approach 2nd ed. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
  • Hartley, D. and Cooper, G.M. 2000. Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925-16932.
  • Lin, H., Jurk, M., Gulick, T., and Cooper, G.M. 1999. Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800.
  • Erhardt, P., Schremser, E.J., and Cooper, G.M. 1999. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 19:5308-5315.
  • Pap, M., and Cooper, G.M. 1998. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/Akt cell survival pathway. J. Biol. Chem. 273:19929-19932.
  • Cooper, G.M. 1997. The Cell: A Molecular Approach. Amer. Soc. Microbiol., Washington and Sinauer Assoc., Sunderland, MA.
  • Dudek, H., Datta, S.R., Franke, T.F., Birnbaum, M.J., Yao, R., Cooper, G.M., Segal, R.A., Kaplan, D.R., and Greenberg, M.E. 1997. Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665.
  • Erhardt, P., Tomaselli, K.J., and Cooper, G.M. 1997. Identification of the MDM2 oncoproteinas a substrate for CPP32-like apoptotic proteases. J. Biol. Chem. 272:15049-15052.
  • Lopes, U.G., Yao, R., and Cooper, G.M. 1997. p53-dependent induction of apoptosis by proteasome inhibitors. J. Biol. Chem. 272:12893-12896.
  • Cooper, G.M. 1995. Oncogenes 2nd ed. Jones and Bartlett Publishers, Boston.
  • Xu, W., and Cooper, G.M. 1995. Identification of a candidate c-mos repressor that restricts transcription of germ cell-specific genes. Mol. Cell. Biol. 15:5369-5375.
  • Yao, R., and Cooper, G.M. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006.

See also[edit]

Geoffry M. Cooper's Lab Site