George Brownlee

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Professor George Brownlee
Born George Gow Brownlee
(1942-01-13)13 January 1942[1]
Fields Pathology
Institutions University of Cambridge
University of Oxford
Laboratory of Molecular Biology
Sir William Dunn School of Pathology
Alma mater Emmanuel College, Cambridge
Thesis Nucleotide sequences in the low molecular weight ribosomal ribonucleic acid of Escherichia coli (1967)
Doctoral advisor Frederick Sanger
Notable awards Fellow of the Royal Society (1987)[2]
FMedSci
Website
www.linc.ox.ac.uk/Fellows/GeorgeBrownlee

Professor George Gow Brownlee FRS FMedSci is a British pathologist and fellow of Lincoln College, Oxford.[3][4][5][6][7]

Education[edit]

Brownlee was educated at the Emmanuel College, Cambridge where he was awarded a Master of Arts degree and PhD supervised by Fred Sanger.[3]

Career[edit]

Brownlee was Professor of Chemical Pathology at Sir William Dunn School of Pathology, from 1978 to 2008.[citation needed]

Brownlee cloned and expressed human clotting factor IX,[8][9] providing a recombinant source of this protein for Haemophilia B patients who had previously relied on the hazardous blood-derived product.

With Merlin Crossley he helped discover the two sets of genetic mutations that were preventing two key proteins from attaching to the DNA of people with a rare and unusual form of Haemophilia B - Haemophilia B Leyden - where sufferers experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty.[10] This lack of protein attachment to the DNA was thereby turning off the gene that produces clotting factor IX, which prevents excessive bleeding.[11]

With Peter Palese and co-workers he developed the first reverse genetics system for influenza virus, markedly speeding up the process of developing influenza vaccines.[citation needed]

Brownlee has written a scientific biography of Fred Sanger for publication in December 2014.[12]

Awards and honours[edit]

Brownlee was elected a Fellow of the Royal Society in 1987.[1] His nomination reads:

Brownlee was also elected a Fellow of the Academy of Medical Sciences (FMedSci).[1]

References[edit]

  1. ^ a b c "BROWNLEE, Prof. George Gow". Who's Who 2013, A & C Black, an imprint of Bloomsbury Publishing plc, 2013; online edn, Oxford University Press. (subscription required)
  2. ^ a b "Library and Archive Catalogue Brownlee". London: The Royal Society. Retrieved 2013-11-11. 
  3. ^ a b "Professor George Brownlee, Lincoln College, Oxford". Archived from the original on 2013-12-17. 
  4. ^ George Brownlee from the Scopus bibliographic database.
  5. ^ Rao, Z.; Handford, P.; Mayhew, M.; Knott, V.; Brownlee, G. G.; Stuart, D. (1995). "The structure of a Ca(2+)-binding epidermal growth factor-like domain: Its role in protein-protein interactions". Cell 82 (1): 131–141. doi:10.1016/0092-8674(95)90059-4. PMID 7606779.  edit
  6. ^ Caton, A. J.; Brownlee, G. G.; Yewdell, J. W.; Gerhard, W. (1982). "The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)". Cell 31 (2 Pt 1): 417–427. doi:10.1016/0092-8674(82)90135-0. PMID 6186384.  edit
  7. ^ Proudfoot, N. J.; Brownlee, G. G. (1976). "3′ Non-coding region sequences in eukaryotic messenger RNA". Nature 263 (5574): 211–214. doi:10.1038/263211a0. PMID 822353.  edit
  8. ^ Choo, K. H.; Gould, K. G.; Rees, D. J. G.; Brownlee, G. G. (1982). "Molecular cloning of the gene for human anti-haemophilic factor IX". Nature 299 (5879): 178–180. doi:10.1038/299178a0. PMID 6287289.  edit
  9. ^ Anson, D. S.; Austen, D. E. G.; Brownlee, G. G. (1985). "Expression of active human clotting factor IX from recombinant DNA clones in mammalian cells". Nature 315 (6021): 683–685. doi:10.1038/315683a0. PMID 2989700.  edit
  10. ^ http://ghr.nlm.nih.gov/condition/hemophilia
  11. ^ http://www.ncbi.nlm.nih.gov/pubmed/2342576
  12. ^ "Fred Sanger, Double Nobel Laureate: A Biography". Cambridge UP. Retrieved 22 August 2014. 

External links[edit]