The George Deffenbaugh Mound is a Native American mound in the southeastern part of the U.S. state of Ohio. Located northeast of Laurelville in Hocking County, the mound sits on a ridgeline; it is 6.5 feet (2.0 m) tall and approximately 50 feet (15 m) in diameter. It was first excavated at an unknown date prior to 1941; at this time, a hole was sunk from the mound's crest to its base, and a smaller hole was dug into its edge.
The mound's location and conical shape indicates that it is a work of the Adena culture, which was active between 1000 BC and AD 400. Occupation of the vicinity was not seemingly limited to the Adena period; approximately 0.3 miles (0.48 km) away from the Deffenbaugh Mound is a stone mound perhaps built by the Fort Ancient culture, perhaps more than one thousand years after the construction of the Deffenbaugh Mound.