SR 115 begins just northeast of the Chestatee River at an intersection with US 19/SR 60 (South Chestatee Street), south of Dahlonega, in Lumpkin County. This intersection marks the northern terminus of SR 400. South of this intersection, US 19/SR 400 make up the Hospitality Highway, a freeway that provides access to Atlanta. It heads northeast to an intersection with SR 52, east of the town. The two routes run concurrent to the southeast for a little over 1 mile (1.6 km). In a curving fashion, SR 115 heads northeast into White County and intersects with the western terminus of SR 284 (Shoal Creek Church Road). Then, it enters Cleveland, where it meets US 129/SR 11 (Main Street). On the eastern edge of town is Truett-McConnell College. Just east of the town is an intersection with the western terminus of SR 255. To the southeast is SR 384 (Duncan Bridge Road). Immediately after is an intersection with the eastern terminus of SR 254. About 0.5 miles (0.80 km) later, the route passes over the Chattahoochee River into Habersham County. To the northeast is an intersection with SR 105 (Cannon Bridge Road). Just before entering Clarkesville, Georgia is an intersection with the southern terminus SR 17 Connector and the beginning of a concurrency with SR 17 (Unicoi Turnpike). The tow highways travel to the southeast until it enters the town. Almost immediately is a crossing over the Soque River. They curve to the northeast until they intersect SR 197/SR 385 (Washington Street, which is part of the old route of US 441). At this intersection, SR 115 ends, and SR 17 heads south concurrent with SR 197/SR 385. The highway is mostly rural, except for the segments in Cleveland and Clarkesville. 
All of SR 115 west of the intersection with SR 105 is part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.