SR 177 begins at an intersection with US 441/SR 89/SR 94 just southeast of Fargo, in Clinch County. It heads northeast, through portions of Ware and Charlton counties. SR 177 enters the Okefenokee Swamp and then the Okefenokee National Wildlife Refuge. Farther to the northeast it enters Stephen C. Foster State Park and ends at a dead end in the northern end of the park.
The route resumes at an intersection with US 1/US 23/SR 4 west of Laura S. Walker State Park, which is located southeast of Waycross, in Ware County. It runs along the southern edge of the park, and very briefly enters Brantley County. SR 177 re-enters Ware County, and enters the park. The highway heads to the north-northwest of US 82/SR 520, north of the park.