SR 33 begins at an intersection with US 84/SR 38 in Boston. The route travels north to Pavo. After a brief concurrency in Pavo with SR 122, SR 33 continues north. South of Moultrie, SR 33 begins a concurrency with US 319 Business. The two routes travel north, through downtown Moultrie. North of the city, US 319 Business departs, and after a brief concurrency with SR 133, the route continues north to Sylvester. In Sylvester, SR 33 has a brief concurrency with SR 112 before departing and continuing north to meet its northern terminus, an intersection with US 41/SR 7 south of Cordele.