Little is known of her early life. By the late 1920s she was singing in clubs in Chicago, and she made her first recording, "When You're Smiling, the Whole World Smiles With You," with Jimmie Noone's orchestra in 1930. She returned to the studio in 1935, and over the next six years recorded over 100 tracks for Decca Records, usually accompanied by the pianist Richard M. Jones and also, in the late 1930s, by guitarist Lonnie Johnson. Her output exceeds that of her rivals Lil Johnson and Merline Johnson, and even Memphis Minnie, during those years.
She also recorded under the name Georgia Lawson. Many of her songs were mildly risqué, including "I'll Keep Sitting on It," "Take Me for a Buggy Ride," "Mama Knows What Papa Wants When Papa's Feeling Blue," and "Hot Nuts." Her best known song was "You Done Lost Your Good Thing Now."
In the 1940s, Georgia White formed an all-women band, which never recorded, and also performed with Bumble Bee Slim. In 1949 she joined Big Bill Broonzy as pianist in his Laughing Trio. "She was very easy to get along with," said Broonzy. "Real friendly."
She returned to singing in clubs in the 1950s, and her last known public performance was in 1959 in Chicago.