Gerald M. Rubin

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Gerald Rubin
Born Gerald Mayer Rubin
1950 (age 64–65)[citation needed]
Fields
Institutions
Alma mater
Thesis Studies on 5.8S ribosomal RNA (1974)
Notable awards
Website
www.hhmi.org/scientists/gerald-m-rubin

Gerald Mayer Rubin (born 1950) is an American biologist, notable for pioneering the use of transposable P elements in genetics, and for leading the public project to sequence the Drosophila melanogaster genome. Related to his genomics work, Rubin's lab is notable for development of genomics tools and whole-genome studies of gene regulation. Rubin also serves as Vice President of the Howard Hughes Medical Institute and Executive Director of the Janelia Farm Research Campus.[2][3][4][5]

Biography[edit]

Rubin was born in Boston, Massachusetts, in 1950, attending the Boston Latin School. Rubin completed his undergraduate degree in biology at MIT, working at Cold Spring Harbor Laboratory during the summer.[6][7] He completed his Ph.D. at the University of Cambridge,[8] funded by the MRC in 1974,[9] for studies on 5.8S ribosomal RNA.

Career[edit]

Following his PhD, Rubin did postdoctoral research at Stanford University with David Hogness.[10]

Rubin's first faculty position was at Harvard Medical School, followed by the Carnegie Institution of Washington; in 1983 he accepted a faculty appointment at the University of California, Berkeley. He was appointed a Howard Hughes Medical Investigator in 1987. He is currently the MacArthur Professor of Genetics, Genomics and Development, in Berkeley's Department of Molecular and Cell Biology.

Rubin has taken a leading role in a number of high-profile scientific research projects.[11][12][13][14][15][16][17][18][19][20][21] As the director of the Berkeley Drosophila Genome Project, he led the public effort to sequence Drosophila melanogaster.[22] As Vice President of the Howard Hughes Medical Institute, Rubin led the development of HHMI's Janelia Farm Research Campus, an independent biomedical research institute in Virginia.[6][7]

His lab is particularly known for its development of genomics tools, studies of gene regulation, and other genome-wide research.

Awards and honours[edit]

Rubin has won numerous awards including:

References[edit]

  1. ^ a b Orr-Weaver, T. (2003). "The 2003 George W. Beadle Medal; Gerald M. Rubin and Allan C. Spradling". Genetics 164 (4): 1248–1249. PMC 1462668. PMID 15106662. 
  2. ^ Gerald M. Rubin's publications indexed by the Scopus bibliographic database, a service provided by Elsevier.
  3. ^ Rubin, G. M. (2006). "Janelia Farm: An Experiment in Scientific Culture". Cell 125 (2): 209–212. doi:10.1016/j.cell.2006.04.005. PMID 16630805. 
  4. ^ Rubin faculty profile
  5. ^ http://www.sciencewatch.com/sept-oct99/sw_sept-oct99_page3.htm HMI's Gerald M. Rubin: The Benefits of Genomics, ScienceWatch, v.10, n.5 (Sept./Oct. 1999)
  6. ^ a b UPI, "Gerald Rubin: Science Far Too Conservative", April 20, 2006 (discussing Janelia Farm).
  7. ^ a b Tim Studt, "Architect of the Future: Refocusing on Basic Research", R&D Magazine.
  8. ^ Rubin, Gerald Mayer (1974). Studies on 5.8 S Ribo-somal RNA (PhD thesis). University of Cambridge. 
  9. ^ Rubin, G. (1974). "Three forms of the 5.8-S ribosomal RNA species in Saccharomyces cerevisiae". European journal of biochemistry / FEBS 41 (1): 197–202. doi:10.1111/j.1432-1033.1974.tb03260.x. PMID 4593336. 
  10. ^ Rubin, G.; Hogness, D. (1975). "Effect of heat shock on the synthesis of low molecular weight RNAs in drosophilia: Accumulation of a novel form of 5S RNA". Cell 6 (2): 207–213. doi:10.1016/0092-8674(75)90011-2. PMID 810246. 
  11. ^ Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H. et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  12. ^ Xu, T; Rubin, G. M. (1993). "Analysis of genetic mosaics in developing and adult Drosophila tissues". Development (Cambridge, England) 117 (4): 1223–37. PMID 8404527. 
  13. ^ Harris, M. A.; Clark, J; Ireland, A; Lomax, J; Ashburner, M; Foulger, R; Eilbeck, K; Lewis, S; Marshall, B; Mungall, C; Richter, J; Rubin, G. M.; Blake, J. A.; Bult, C; Dolan, M; Drabkin, H; Eppig, J. T.; Hill, D. P.; Ni, L; Ringwald, M; Balakrishnan, R; Cherry, J. M.; Christie, K. R.; Costanzo, M. C.; Dwight, S. S.; Engel, S; Fisk, D. G.; Hirschman, J. E.; Hong, E. L. et al. (2004). "The Gene Ontology (GO) database and informatics resource". Nucleic Acids Research 32 (Database issue): D258–61. doi:10.1093/nar/gkh036. PMC 308770. PMID 14681407. 
  14. ^ Spradling, A.; Rubin, G. (1982). "Transposition of cloned P elements into Drosophila germ line chromosomes". Science 218 (4570): 341–347. Bibcode:1982Sci...218..341S. doi:10.1126/science.6289435. PMID 6289435. 
  15. ^ Rubin, G.; Spradling, A. (1982). "Genetic transformation of Drosophila with transposable element vectors". Science 218 (4570): 348–353. Bibcode:1982Sci...218..348R. doi:10.1126/science.6289436. PMID 6289436. 
  16. ^ Miklos, G.; Rubin, G. (1996). "The role of the genome project in determining gene function: Insights from model organisms". Cell 86 (4): 521–529. doi:10.1016/S0092-8674(00)80126-9. PMID 8752207. 
  17. ^ Adams, M.; Celniker, S.; Holt, R.; Evans, C.; Gocayne, J.; Amanatides, P.; Scherer, S.; Li, P.; Hoskins, R.; Galle, R. F.; George, R. A.; Lewis, S. E.; Richards, S.; Ashburner, M.; Henderson, S. N.; Sutton, G. G.; Wortman, J. R.; Yandell, M. D.; Zhang, Q.; Chen, L. X.; Brandon, R. C.; Rogers, Y. H.; Blazej, R. G.; Champe, M.; Pfeiffer, B. D.; Wan, K. H.; Doyle, C.; Baxter, E. G.; Helt, G.; Nelson, C. R. (2000). "The genome sequence of Drosophila melanogaster". Science 287 (5461): 2185–2195. Bibcode:2000Sci...287.2185.. doi:10.1126/science.287.5461.2185. PMID 10731132. 
  18. ^ Rubin, G.; Yandell, M.; Wortman, J.; Gabor Miklos, G.; Nelson, C.; Hariharan, I.; Fortini, M.; Li, P.; Apweiler, R.; Fleischmann, W.; Cherry, J. M.; Henikoff, S.; Skupski, M. P.; Misra, S.; Ashburner, M.; Birney, E.; Boguski, M. S.; Brody, T.; Brokstein, P.; Celniker, S. E.; Chervitz, S. A.; Coates, D.; Cravchik, A.; Gabrielian, A.; Galle, R. F.; Gelbart, W. M.; George, R. A.; Goldstein, L. S.; Gong, F.; Guan, P. (2000). "Comparative genomics of the eukaryotes". Science 287 (5461): 2204–2215. Bibcode:2000Sci...287.2204.. doi:10.1126/science.287.5461.2204. PMC 2754258. PMID 10731134. 
  19. ^ Botstein, D.; Cherry, J. M.; Ashburner, M.; Ball, C. A.; Blake, J. A.; Butler, H.; Davis, A. P.; Dolinski, K.; Dwight, S. S.; Eppig, J. T.; Harris, M. A.; Hill, D. P.; Issel-Tarver, L.; Kasarskis, A.; Lewis, S.; Matese, J. C.; Richardson, J. E.; Ringwald, M.; Rubin, G. M.; Sherlock, G. (2000). "Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium". Nature Genetics 25 (1): 25–29. doi:10.1038/75556. PMC 3037419. PMID 10802651.  open access publication - free to read
  20. ^ Rubin, G. M. (2001). "The draft sequences: Comparing species". Nature 409 (6822): 820–821. doi:10.1038/35057277. PMID 11236995. 
  21. ^ Spellman, P. T.; Rubin, G. M. (2002). "Evidence for large domains of similarly expressed genes in the Drosophila genome". Journal of Biology 1 (1): 5. doi:10.1186/1475-4924-1-5. PMC 117248. PMID 12144710. 
  22. ^ Adams, M.; Celniker, S.; Holt, R.; Evans, C.; Gocayne, J.; Amanatides, P.; Scherer, S.; Li, P.; Hoskins, R.; Galle, R. F.; George, R. A.; Lewis, S. E.; Richards, S.; Ashburner, M.; Henderson, S. N.; Sutton, G. G.; Wortman, J. R.; Yandell, M. D.; Zhang, Q.; Chen, L. X.; Brandon, R. C.; Rogers, Y. H.; Blazej, R. G.; Champe, M.; Pfeiffer, B. D.; Wan, K. H.; Doyle, C.; Baxter, E. G.; Helt, G.; Nelson, C. R. (2000). "The genome sequence of Drosophila melanogaster". Science 287 (5461): 2185–2195. Bibcode:2000Sci...287.2185.. doi:10.1126/science.287.5461.2185. PMID 10731132. 
  23. ^ Robert Sanders, "UC Berkeley's Gerald Rubin shares AAAS prize with Celera's Craig Venter for sequencing genome of the fruit fly", UC Berkeley Campus News, Feb. 20, 2001.