Germ-free animals are animals that have no microorganisms living in or on it. Such animals are raised within germ-free isolators in order to control their exposure to viral, bacterial or parasitic agents. When known strains of bacteria or microbiota are introduced to a germ-free animal, it usually referred to as a gnotobiotic animal, however technically speaking, germ-free animals are also gnotibiotic because the status of their microbial community is known.
- University of Michigan Germ Free Animal Facility - example facility for raising germ-free animals
- Reyniers, J.A. Germfree Vertebrates: Present Status (1959) Annals of the New York Academy of Sciences. 78(1):3.
- Of Probiotics and Possibilities - J. Armbrecht. Dept of Bacteriology, University of Wisconsin-Madison. August 2, 2000.
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