Khatib was formerly the Director of the Jerusalem Media and Communications Center (JMCC), a non-governmental organization that conducts public opinion polls and provides media support to journalists in the Palestinian territories. A long-time advocate of Palestinian-Israeli dialogue, he appeared in a peace making mission in the 2009 film 'Bruno'. Khatib co-founded and was director of bitterlemons.org, a Palestinian-Israeli internet-based political magazine. Khatib was also the President of the Board of Directors of the Arab Development Center, an agricultural development organization and a member of the Advisory Board of Palestinian Politics. He also served as co-founder of the Democracy and Workers' Rights Center and a member of the Board of Trustees of the Friends Schools in Palestine. Khatib regularly lectures at the Cultural Studies Program of Bir Zeit University.