Giacinto Gimignani (1606–1681) was an Italian painter, active mainly in Rome, during the Baroque period.
Gimignani was born in Pistoia, where his father, Alessio (1567–1651) was also a painter and former pupil of Jacopo Ligozzi. In Pistoia, are a number of paintings in the Museo Rospigliosi, including the Meeting of Venus and Adonis and The brothers show Joseph's bloody coat to Jacob. Gimignani had been patronized by the prominent Guido Rospigliosi, Cardinal Secretary of State, and descendant of a prominent family of Pistoia. By 1630 he travels to Rome, and by 1632 he was working for Pietro da Cortona. His first known work is the fresco of the Rest on the Flight to Egypt (1632), a lunette in the chapel of the Palazzo Barberini.
He also painted the fresco of the Vision of Constantine in the ambulatory of the baptistery of San Giovanni in Laterano under the guidance of Andrea Sacchi. In 1648 he assisted Cortona in the decoration of the Palazzo Pamphili in Rome. He developed a classical style befitting the grand manner style developing in Rome. He was also an etcher. His son Ludovico Gimignani is also known for his work in Rome.