Giant platelet disorder
|Giant platelet disorder|
|Classification and external resources|
Two giant platelets (stained purple) are visible in this image from a light microscope (40×) from a peripheral blood smear surrounded by red blood cells. One normal platelet can be seen in the upper left side of the image (purple) and is significantly smaller in size than the red blood cells (stained pink).
Giant platelet disorders are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelet disorder occurs for inherited diseases like Bernard-Soulier syndrome, gray platelet syndrome and May-Hegglin anomaly.
Giant platelet disorders can be further categorized:
- Caused by glycoprotein abnormalities: Bernard-Soulier syndrome, Velocardiofacial syndrome
- Caused by calpain defect: Montreal platelet syndrome
- Caused by alpha granules defect: Gray platelet syndrome
- Characterized by abnormal neutrophil inclusions: May-Hegglin anomaly, Sebastian syndrome
- With systemic manifestations: Hereditary macrothrombocytopenia with hearing loss, Epstein syndrome, Fechtner syndrome
- With no specific abnormalities: Mediterranean macrothrombocytopenia
- Harris platelet syndrome
Signs and symptoms
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