Gilean McVean

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Gil McVean
Gilean McVean.JPG
Gilean McVean speaking at the 2010 GEM meeting at the WTSI, Hinxton.
Institutions University of Oxford, University of Edinburgh
Alma mater University of Cambridge
Doctoral advisor Laurence Hurst[1]
Other academic advisors Brian Charlesworth and Deborah Charlesworth
Doctoral students Adam Auton, Niall Cardin, Ella Chase, Jo Gay, Chris Hallsworth, Loukas Moutsianas, Chris Spencer, Daniel Wilson[2]
Notable awards Crick Lecture 2010[3]

Gilean "Gil" McVean is a professor of statistical genetics at the University of Oxford[4] and a fellow of Linacre College, Oxford. He is a member of the 1000 Genomes Project steering committee.

Education and employment[edit]

McVean completed his PhD in the Department of Genetics, at the University of Cambridge with Laurence Hurst[5][6] in 1997.[7] He then completed a postdoc at the University of Edinburgh under the supervision of Brian Charlesworth and Deborah Charlesworth.[8] From 2000-2004 he was a Royal Society University Research Fellow, in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004.

His research[9] focuses on population genetics, statistics[10] and evolutionary biology including the International HapMap Project,[11][12] recombination rates in the human genome[13] and the 1000 Genomes Project.[14][15]


  1. ^ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current biology : CB 6 (5): 533–536. doi:10.1016/S0960-9822(02)00535-3. PMID 8805261.  edit
  2. ^ McVean group members
  3. ^ Crick Lectures
  4. ^ McVean Group at the University of Oxford
  5. ^ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature 386 (6623): 388–392. doi:10.1038/386388a0. PMID 9121553.  edit
  6. ^ Hurst, L.D.; McVean, G.T. (1996). "... And scandalous symbionts". Nature 381 (6584): 650–651. doi:10.1038/381650a0. PMID 8649507.  edit
  7. ^ Gilean McVean Oxford University
  8. ^ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in ecology & evolution 16 (5): 235–242. doi:10.1016/S0169-5347(01)02126-7. PMID 11301152.  edit
  9. ^ Gilean McVean in Google Scholar
  10. ^ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M.; Sabeti, P. C. (2011). "Detecting Novel Associations in Large Data Sets". Science 334 (6062): 1518–1524. doi:10.1126/science.1205438. PMC 3325791. PMID 22174245.  edit
  11. ^ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; Zhang, H. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature 449 (7164): 851–861. doi:10.1038/nature06258. PMC 2689609. PMID 17943122.  edit
  12. ^ Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; Gao, Yang (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature 449 (7164): 913–918. doi:10.1038/nature06250. PMC 2687721. PMID 17943131.  edit
  13. ^ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science 304 (5670): 581–584. doi:10.1126/science.1092500. PMID 15105499.  edit
  14. ^ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011). "The Variant Call Format and VCFtools". Bioinformatics 27 (15): 2156–2158. doi:10.1093/bioinformatics/btr330. PMC 3137218. PMID 21653522.  edit
  15. ^ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science 331 (6019): 920–924. doi:10.1126/science.1198878. PMC 3669691. PMID 21330547.  edit