Gilles-Éric Séralini

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Gilles-Éric Séralini
Born (1960-08-23)August 23, 1960
Bône, Algeria (then French Algeria)
Residence Caen, France
Fields Endocrinology
Institutions University of Caen
Alma mater University of Montpellier II
Thesis Rôle inhibiteur de l'alphafoetoprotéine sur la fonction génitale du rat (1987)
Known for Genetically modified food controversies, Seralini affair
Notable awards Knight of the National Order of Merit[1]
Spouse Soline Séralini[2]
Children Two

Gilles-Éric Séralini is a French scientist who has been a professor of molecular biology at the University of Caen since 1991. He is best known for publishing research concluding that genetically modified food is unsafe for consumption; one such study, published in September 2012 in Food and Chemical Toxicology prompted many headlines about the dangers of Roundup Ready corn and the Roundup herbicide. The study was subject to considerable criticism by members of the scientific community and was eventually retracted[3][4] in what has become known as the Seralini affair. On June 24, 2014 the study was republished by Environmental Sciences Europe.[5]

Early life[edit]

Seralini was born on August 23, 1960 in Annaba, Algeria (then known as Bône). His father was a telecommunications technician and his mother was a schoolteacher.[6] When Seralini was 5 years old, his younger brother, Marc, suffered a serious vaccine injury, with regard to which Séralini has said he has been "marked for life."[2] His family first settled in Thonon-les-Bains, Haute Savoie, and then Nice, France. Seralini obtained his baccalaureate degree at the age of 16.

Scientific career[edit]

In 1987, Seralini obtained his doctoral degree from the University of Montpellier II. He then did four years of research at, among other places, the University of Western Ontario and Laval University Medical Center, doing research on corticosteroid-binding globulin, before being appointed a professor at the University of Caen in June 1991, a position he has held ever since. The general area of his lab's research focuses on the endocrine system, in particular the enzyme aromatase, and his lab has synthesized a number of aromatase inhibitors using equine aromatase as a model.[7] In addition to the safety of genetically modified food, Seralini's more recent research has focused on the effects of the glyphosate-based herbicide Roundup on human cells and the enzyme aromatase in vitro,[8] as well as rat testicular cells.[9] In general, this in vitro research has concluded that Roundup (the formulation with adjuvants, not just glyphosate) is toxic to cells in a dish, as well as that it is an endocrine disruptor. The cell lines tested include HUVEC, HEK cells, and placental JEG-3 cells,[10][11][12] as well as HepG2 cells.[8] In 2013, the Seralini lab published a study is one that examines the effects of Cry1ab and Cry1ac insecticidal Bt toxins, as well as their effects in conjunction with Roundup, on HEK cells.[13] His research has been published in the Journal of Histochemistry & Cytochemistry, the Journal of Steroid Biochemistry and Molecular Biology, and Molecular and Cellular Endocrinology.

In 2014, Seralini et al. published a study claiming that pesticides were more toxic than regulatory bodies had previously thought.[14] The study prompted Ralf Reski, one of the editors of BioMed Research International, the journal in which it was published, to resign. Reski said, "I do not want to be connected to a journal that provides [Séralini] a forum for such kind of agitation."[15]

Debate[edit]

In May 2013, shortly before a debate was scheduled to take place on the topic of genetically modified foods, held by the Cato Institute, both Professor Seralini and fellow anti-GMO activist Jeffrey M. Smith withdrew from the debate, with Smith disapproving of the planned inclusion of molecular biologist Kevin Folta and Seralini accusing Jon Entine, who organized the debate's panel, of libel.[16]

Selected publications[edit]

Scientific papers[edit]

  • Almadhidi, J.; Seralini, G. E.; Fresnel, J.; Silberzahn, P.; Gaillard, J. L. (1995). "Immunohistochemical localization of cytochrome P450 aromatase in equine gonads". The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 43 (6): 571–577. doi:10.1177/43.6.7769228. PMID 7769228.  edit
  • Le Curieux-Belfond, O.; Moslemi, S.; Mathieu, M.; Séralini, G. E. (2001). "Androgen metabolism in oyster Crassostrea gigas: Evidence for 17β-HSD activities and characterization of an aromatase-like activity inhibited by pharmacological compounds and a marine pollutant". The Journal of Steroid Biochemistry and Molecular Biology 78 (4): 359–366. doi:10.1016/S0960-0760(01)00109-1. PMID 11717006.  edit
  • Lemazurier, E.; Sourdaine, P.; Nativelle, C. L.; Plainfossé, B.; Séralini, G. E. (2001). "Aromatase gene expression in the stallion". Molecular and Cellular Endocrinology 178 (1–2): 133–139. doi:10.1016/S0303-7207(01)00435-X. PMID 11403902.  edit

Books[edit]

References[edit]

  1. ^ "Pr Séralini was Made a Knight by Nathalie Kosciusko-Morizet: May 2008". CRIIGEN. 2008. Retrieved 27 January 2014. 
  2. ^ a b Guilhot, Alain (21 November 2012). "Gilles-Eric Seralini: The Rat Man". LeMonde.fr. Retrieved 3 September 2013. 
  3. ^ "Elsevier Announces Article Retraction from Journal Food and Chemical Toxicology". Elsevier. Retrieved 2013-11-29. 
  4. ^ Kate Kelland. "Journal withdraws controversial French Monsanto GM study". 
  5. ^ "Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize". Environmental Sciences Europe. 
  6. ^ Noualhat, Laure (19 October 2012). "Gilles-Eric Seralini: GMOs at all". Liberation.fr. Retrieved 27 August 2013. 
  7. ^ Séralini, G. E.; Moslemi, S. (2001). "Aromatase inhibitors: Past, present and future". Molecular and Cellular Endocrinology 178 (1–2): 117–131. doi:10.1016/S0303-7207(01)00433-6. PMID 11403901.  edit
  8. ^ a b Gasnier, C.; Dumont, C.; Benachour, N.; Clair, E.; Chagnon, C.; Séralini, E. (Jun 2009). "Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines". Toxicology 262 (3): 184–191. doi:10.1016/j.tox.2009.06.006. ISSN 0300-483X. PMID 19539684.  edit
  9. ^ Clair, É.; Mesnage, R.; Travert, C.; Séralini, G. É. (2012). "A glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels". Toxicology in Vitro 26 (2): 269–279. doi:10.1016/j.tiv.2011.12.009. PMID 22200534.  edit
  10. ^ Benachour, N.; Séralini, G. E. (2009). "Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells". Chemical Research in Toxicology 22 (1): 97–105. doi:10.1021/tx800218n. PMID 19105591.  edit
  11. ^ Richard, S. M.; Moslemi, S.; Sipahutar, H.; Benachour, N.; Seralini, G. E. (Jun 2005). "Differential Effects of Glyphosate and Roundup on Human Placental Cells and Aromatase". Environmental health perspectives 113 (6): 716–720. doi:10.1289/ehp.7728. ISSN 0091-6765. PMC 1257596. PMID 15929894.  edit
  12. ^ Benachour, N.; Sipahutar, H.; Moslemi, S.; Gasnier, C.; Travert, C.; Séralini, G. (2007). "Time- and dose-dependent effects of roundup on human embryonic and placental cells". Archives of environmental contamination and toxicology 53 (1): 126–133. doi:10.1007/s00244-006-0154-8. PMID 17486286.  edit
  13. ^ Mesnage, R.; Clair, E.; Gress, S.; Then, C.; Székács, A.; Séralini, G. -E. (2013). "Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide". Journal of Applied Toxicology 33 (7): 695–699. doi:10.1002/jat.2712. PMID 22337346.  edit
  14. ^ Mesnage, Robin; Defarge, Nicolas; Spiroux de Vendômois, Joël; Séralini, Gilles-Eric (2014). "Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles". BioMed Research International 2014: 1–8. doi:10.1155/2014/179691. 
  15. ^ Kupferschmidt, Kai (10 February 2014). "Pesticide Study Sparks Backlash". Science Insider. Retrieved 16 March 2014. 
  16. ^ Entine, Jon (29 May 2013). "Anti-GMO Scientist Gilles-Eric Seralini, Activist Jeffrey Smith Withdraw from Food Biotech Debate". Forbes.com. Retrieved 4 September 2013.