Giovanni Andrea Sirani (4 September 1610 – 21 May 1670) was an Italian Baroque painter from Bologna.
He is best known as the father of the female painter Elisabetta Sirani. Sirani trained initially with Giacomo Cavedone, then worked in the studio with Guido Reni. He became entangled in various conspiracies circling around the death of his daughter in 1665. Giovanni accused a maid of poisoning her; others accuse Giovanni of causing her to develop a stomach ulcer from overwork.