His masterpiece is said to be frescoes in the chapel of the Palazzo Rospigliosi-Pallavicini in Pistoia. While escaping Florence during the plague, he painted some frescoes in the lunettes in the Santuario della Madonna della Fontenuova in Monsummano Terme. On the left internal wall of the chorus of the church of San Bartolomeo in Cutigliano, is a canvas of Mannozzi's the Circumcision (1620). He painted a fresco cycle on the vault of the Mellini Chapel in Santa Maria del Popolo which displays The Story of Saint Nicholas of Tolentino in 1623-24.
He died in 1636 and was buried in the church of San Pier Gattolino in Florence.