The first reference in a historical document which mentions the Castel di Juvo, including its location overlooking the Tiber Valley, dates to 1191. The castle was part of lands fought over by the lords of Alviano and the Roman Catholic Church. In 1481 Pope Sixtus IV gave the fief of to Lucrezia Appiani of Aragon, widow of Pino III Ordelaffi. The castle and lands are purchased by the Farnese family in 1514. They sell the fief of Giove for 65,000 scudi to the Mattei brothers Ciriaco and Asdrubale; the transfer was confirmed by Pope Clement VIII.