The record features a more blues-influenced sound than their previous albums and contains the hits "Wild Side" and "Girls, Girls, Girls." The record also reflects the band's hard-living lifestyle, and pays homage to their love of riding Harley Motorcycles, drinking whiskey, drug use, life on the Sunset Strip, and spending nights at strip clubs. However, there are darker sides to the album as well, notably Nikki Sixx's song "Dancing on Glass", about his addiction to heroin, and "Wild Side", which tells of destructive lifestyles and the pitfalls of decadence. The song, "Nona" is a tribute to Nikki Sixx' grandmother, who died during the recording of the album.
Girls, Girls, Girls received a positive review from Allmusic's Steve Huey, who gave the album a rating of four stars and states: "Girls, Girls, Girls continued Mötley Crüe's commercial hot streak, eventually going quadruple platinum as its predecessor, Theatre of Pain, had; meanwhile, the title track brought them their second Top 20 single, and 'Wild Side' became a popular MTV item."
The album peaked at No. 2 on the Billboard charts. On the week it might have reached No. 1, Whitney Houston's second album, Whitney, debuted at the top of the charts. Eventually, the group's 1989 album Dr. Feelgood would go on to claim the top Billboard spot. Members of the band have stated that if they hadn't managed to write two successful songs that this album would have been the end of their careers. This is because they were all fighting addictions to drugs and alcohol. The power ballad "You're All I Need" tells the story about the death of a lover.