The song was released as a radio single on January 5, 2010. Upon its release as a single, the song has adopted the extended title, "Give Me a Sign (Forever and Ever)". The song reached #97 on the Billboard Hot 100. It was far more successful on the Billboard rock charts, reaching #6 on the Hot Mainstream Rock Tracks chart, #9 on the Rock Songs chart, and #10 on the Alternative Songs chart.
An acoustic version was released by the band on January 13, 2010. The acoustic version was placed on the Japanese import release of Dear Agony.
On February 17, a music video was put into the planning process. The band shot the video for "Give Me a Sign" with acclaimed director Nigel Dick. While singer Ben Burnley said he had not completely divulged the concept, he added an element of suspense by stating that he hoped fans of the band would “recognize and be excited by the inclusion of certain key characters from the band’s past”. The video premiered on their Myspace page on March 10, which happened to be Benjamin Burnley's 32nd birthday. It is the last Breaking Benjamin video to feature Aaron Fink, Mark Klepaski, and Chad Szeliga.
The music video shows a young woman rushed in to a hospital, her fiancé, an old man, and a young child. A man whose face can't be seen comes into their rooms and takes their hands. Each room features artwork from Breaking Benjamin's albums. The young boy's room has a picture of the cover art from Saturate. The old man with the Breaking Benjamin tattoo on his finger is from the cover of We Are Not Alone. The faceless man is the "Evil Angel" from the cover of Phobia, and the song of the same name; and the woman in the hospital bed resembles Jane from "The Diary of Jane" music video. Her room features the MRI scan of Ben's head from the cover of Dear Agony.