Glassy cell carcinoma of the cervix

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Glassy cell carcinoma of the cervix
Classification and external resources
Glassy cell carcinoma - very high mag.jpg
Micrograph of a glassy cell carcinoma of the cervix. H&E stain.

Glassy cell carcinoma of the cervix, also glassy cell carcinoma, is a rare aggressive malignant tumour of the uterine cervix.[1] The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.

Signs and symptoms[edit]

The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.

Diagnosis[edit]

The diagnosis is based on tissue examination, e.g. biopsy.

Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining distinctively extenuates the plasma membrane.[2]

Treatment[edit]

The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.[2]

See also[edit]

Additional images[edit]

References[edit]

  1. ^ Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix.". J Obstet Gynaecol Res 35 (3): 584–7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406. 
  2. ^ a b Deshpande, AH.; Kotwal, MN.; Bobhate, SK. "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature.". Indian J Cancer 41 (2): 92–5. PMID 15318016. 

External links[edit]