To enroll in Global Entry, applicants must first file an application with Customs and Border Protection, and then submit to an interview and background check. There is a $100 non-refundable fee for the application. During the interview, the applicant's fingerprints are captured and a digital photo is taken. Applicants are also given instruction on how to use the automated kiosk. Once an application is approved, the applicant may use the Global Entry kiosk at any participating airport for a duration of 5 years. Renewal requires an additional fee.
Enrolled users must present their machine-readable Passport or permanent residency card and submit their fingerprints to establish identity. Users then complete a computerized Customs Declaration, and are issued a receipt instructing them to either proceed to baggage claim, or to a normal inspection booth for a normal interview.
According to the Global Entry website, "Global Entry is open to U.S. citizens, lawful permanent residents, Dutch citizens, South Korean citizens, German citizens (this is in pilot phase and German citizens wishing to participate in Global Entry must already be members of Easypass), and Mexican nationals. Canadian and United States citizens who are members of the NEXUS program receive Global Entry benefits.
On 27 September 2013, India welcomed an offer of membership to the U.S. Global Entry Trusted Traveler Network Program by the United States.
Members of Global Entry (along with members of NEXUS and SENTRI), may use TSA PreCheck on all participating airlines by entering their Customs and Border Protection ID number from their Global Entry card into their flight reservation information or into their frequent flyer account.
During the 1990s and early 2000s, the U.S.Immigration and Naturalization Service operated INSPASS, a trusted traveler program designed to integrate with Canadian and European programs, at New York-JFK and Newark Airport. INSPASS operated with a similar system, identifying travelers with their handprint. The program was discontinued in 2002 when the INS was merged with U.S. Customs to form U.S. Customs and Border Protection.
The Global Entry program was initially deployed at a small number of airports, including New York-JFK (Terminal 4), Washington-Dulles and Houston-Intercontinental. Following a good reception by travelers, the program was expanded to include Los Angeles International, Atlanta-Hartsfield, Chicago-O'Hare and Miami International Airport.
In May 2009, Global Entry membership was expanded to include Netherlands citizens who are also members of The Netherlands Privium trusted traveler program under the FLUX (Fast Low-risk Universal Crossing) alliance. Present members of Global Entry are now permitted to apply to join the Privium program at Amsterdam-Schiphol International Airport allowing entry into the Schengen area. Members of NEXUS and SENTRI are also entitled to use Global Entry.
- Baltimore/Washington International Thurgood Marshall Airport (BWI)
- Boston-Logan International Airport (BOS)
- Calgary International Airport (YYC)
- Charlotte-Douglas International Airport (CLT)
- Chicago O'Hare International Airport (ORD)
- Dallas/Ft. Worth International Airport (DFW)
- Denver International Airport (DEN)
- Detroit Metropolitan Airport (DTW)
- Dublin Airport (DUB)*
- Edmonton International Airport (YEG)
- Ft. Lauderdale/Hollywood International Airport (FLL)
- Guam International Airport (GUM)*
- Halifax Stanfield International Airport (YHZ)
- Hartsfield-Jackson Atlanta International Airport (ATL)
- Honolulu International Airport (HNL)
- Houston George Bush Intercontinental Airport (IAH)
- John F. Kennedy International Airport, New York (JFK)
- John Wayne Airport (SNA)*
- Los Angeles International Airport (LAX)
- McCarran International Airport, Las Vegas (LAS)
- Miami International Airport (MIA)
- Minneapolis/St. Paul International Airport (MSP)
- Montreal Pierre Elliott Trudeau International Airport (YUL)
- Newark Liberty International Airport (EWR)
- Orlando International Airport (MCO)
- Orlando-Sanford International Airport (SFB)
- Ottawa Macdonald-Cartier International Airport (YOW)
- Philadelphia International Airport (PHL)
- Phoenix Sky Harbor International Airport (PHX)
- Portland International Airport (PDX)
- Raleigh-Durham International Airport (RDU)*
- Saipan International Airport (SPN)*
- Salt Lake City International Airport (SLC)
- San Antonio International Airport (SAT)
- San Diego International Airport (SAN)*
- San Francisco International Airport (SFO)
- San Juan-Luis Muñoz Marin International Airport (SJU)
- Seattle-Tacoma International Airport-SeaTac (SEA)
- Shannon Airport (SNN)*
- Tampa International Airport (TPA)
- Toronto Pearson International Airport (YYZ)
- Vancouver International Airport (YVR)
- Washington-Dulles International Airport (IAD)
- Winnipeg James Armstrong Richardson International Airport (YWG)
The * indicate that there are no enrollment centers at these sites
Analogous systems in other countries
Mexico's Viajero Confiable program is open to Mexican citizens and US citizens who are members of Global Entry. Prospective members must pass a background check, interview with a Mexican immigration officer and have fingerprints and retina scans taken. Kiosks are currently available at Mexico City, Cancun and Los Cabos international airports, but the Mexican government hopes to expand it to other cities in the near future. 
The Australian SmartGate system is available to all Australian and New Zealand citizens with a biometric passport and requires no preregistration. It is similar to its US counterpart however uses facial recognition technology to process passengers. Use of the Australian SmartGate is now open to those enrolled in the US Global Entry Trusted Traveler system.
The e-Channel in Hong Kong is situated at all border crossing points. A person who holds a Hong Kong permanent identity card (SmartID) inserts the card into a slot and gets fingerprinted to pass through the gate.
Taiwan's e-Gate is a free automated entry system for citizens and certain classes of residents and frequent visitors. Users simply scan their travel documents at the gate and are passed through for facial recognition. Electronic fingerprinting is used when facial recognition fails. Registration is available at the immigration counter right at the port of entry.
Germany's federal police also offers Easypass automated border control at major airports such as Frankfurt. It recently started a pilot called ABG+ with GlobalEntry. 
- NEXUS (US-Canada trusted traveler program)
- SENTRI (US-Mexico trusted traveler program)
- INSPASS (The predecessor to Global Entry)
- CANPASS (The Canadian trusted traveler program)
- U.S. Customs and Border Patrol - Global Entry Trusted Traveler Network
- Global Entry travel guide from Wikivoyage
- http://www.globalentry.gov/faq.html#e1 Global Entry Frequently Asked Questions
- http://cbp.gov/xp/cgov/travel/trusted_traveler/global_entry/global_entry_discription.xml CBP - How to Use the Kiosk
- http://www.globalsecurity.org/security/systems/inspass.htm USPASS (formerly INSPASS)
- http://cbp.gov/xp/cgov/travel/trusted_traveler/global_entry/global_entry_flux.xml Global Entry FLUX