Globoidnan A
| Globoidnan A | |
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(2R)-(3,4-dihydroxyphenyl)-2-{[4-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2-naphthoyl]oxy}propanoic acid |
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| Identifiers | |
| CAS number | 827322-48-5  |
| PubChem | 3013628 |
| ChemSpider | 26333277  |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C26H20O10 |
| Molar mass | 492.43 g mol−1 |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Globoidnan A is a lignan found in Eucalyptus globoidea, a tree native to Australia.
The molecule has been found to inhibit the action of HIV integrase,[1] an enzyme which is responsible for the introduction of HIV viral RNA into a host's cellular DNA. So far it is not known that globoidnan A inhibits the action of other retroviral integrases, although it is likely that this possibility will be investigated further.
References [edit]
- ^ Ovenden SP, Yu J, Wan SS, et al. (2004). "Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase". Phytochemistry 65 (24): 3255–9. doi:10.1016/j.phytochem.2004.10.006. PMID 15561191.
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