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|Brain: Globus pallidus|
|Globus pallidus labeled at bottom right.|
|DA-loops in PD|
The globus pallidus (Latin for "pale globe") also known as paleostriatum, is a sub-cortical structure of the brain. It is part of the telencephalon, but retains close functional ties with the subthalamus - both of which are part of the extrapyramidal motor system. The globus pallidus is a major component of the basal ganglia core along with the striatum and its direct target, the substantia nigra. The latter are made up of similar neuronal elements, have similar afferents from the dorsal striatum and have a similar synaptology; neither receives cortical afferents.
The globus pallidus is a structure in the brain which is involved in the regulation of voluntary movement. It is part of the basal ganglia, which, among many other things, regulate movements which occur on the subconscious level. If the globus pallidus is damaged, it can cause movement disorders, as its regulatory function will be impaired. There may be cases in which damage is deliberately induced, as in a procedure known as a pallidotomy, in which a lesion is created to reduce involuntary muscle tremors. When it comes to regulation of movement, the globus pallidus has a primarily inhibitory action which balances the excitatory action of the cerebellum. These two systems are designed to work in harmony with each other to allow people to move smoothly, with even, controlled movements. Imbalances can result in tremors, jerks, and other movement problems, as seen in some people with progressive neurological disorders characterized by symptoms like tremors. The basal ganglia act on a subconscious level, requiring no conscious effort to function. When someone makes a decision to engage in an activity such as petting a cat, for example, these structures help to regulate the movement to make it as smooth as possible, and to respond to sensory feedback. Likewise, the globus pallidus is involved in the constant subtle regulation of movement which allows people to walk, talk, and engage in a wide variety of other activities with a minimal level of disruption.
This area of the basal ganglia receives input from another area, called the striatum, which has two parts, the caudate nucleus and the putamen. This data is routed to the thalamus, either directly or indirectly. In the case of the interna, one area of the globus pallidus, the structure can feed directly to the thalamus. The externa, which lies, as one might imagine, on the outside of this structure, feeds information to the interna, where it can be passed on to the thalamus.
In primates, the dorsal pallidum, or globus pallidus, is divided into two parts by the medial medullary lamina. These are often termed "internal" and "external" (the internal globus pallidus [GPi] and the external globus pallidus [GPe]); both are composed of closed nuclei surrounded by myelinic walls.
The ventral pallidum lies within the substantia innominata (Latin for unnamed substance) and receives efferent connections from the ventral striatum (the nucleus accumbens and the olfactory tubercle). It projects to the dorsomedial nucleus of the dorsal thalamus, which, in turn, projects to the prefrontal cortex; it also projects to the pedunculopontine nucleus and tegmental motor areas. Its function is to serve as a limbic-somatic motor interface, and it is involved in the planning and inhibition of movements from the dorsal striatopallidal complex.
Pallidal nuclei are made up of the same neuronal components. In primates, almost all pallidal neurons are very large, parvalbumin-positive, with very large dendritic arborizations. These have the peculiarity of having the three-dimensional shape of flat discs, parallel to one another, parallel to the border of the pallidum and perpendicular to the afferent striatopallidal axons. There are only a few small local circuitry neurons.
The globus pallidus is traversed by the numerous myelinated axons of the striato-pallidonigral bundle that give it the pale appearance from which it is named.
Pallidonigral pacemaker 
The two pallidal nuclei and the two nigral (pars compacta and pars reticulata) parts constitute a high-frequency autonomous pacemaker (see primate basal ganglia system#Pallido-nigral_set_and_pacemaker)
Common afferents 
The two parts receive successively a large quantity of GABAergic axonal terminal arborisations from the striatum through the dense striato-pallidonigral bundle. The synaptology is very peculiar (see primate basal ganglia system). The striatal afference contribute for more than 90% of synapses. The two pallidal nuclei receives dopaminergic axons from the pars compacta of the substantia nigra.
History of name 
The origin of the name is not established. It was known by Dejerine (1906) but not by Santiago Ramón y Cajal (1909–1911). As the elements in no way have the shape of a globe, Foix and Nicolesco (1925), the Vogts (1941), Crosby et al. (1962) followed by the Terminologia anatomica proposed the simpler term (neuter adjective) of pallidum ("pale"). For a long time the globus pallidus was linked to the putamen and termed the lentiform nucleus (nucleus lenticularis or lentiformis), a heterogeneous anatomical entity that is part of the striatum rather than the pallidum. The link with the substantia nigra pars reticulata was stressed very early on due to the similarities in dendritic arborisation (and they are sometimes known as the pallidonigral set) but, in spite of strong evidence, this association remains controversial.
Additional images 
See also 
- Theme atlas of anatomy: head and neuroanathomy.
- Yelnik, J., Percheron, G., and François, C. (1984) A Golgi analysis of the primate globus pallidus. II- Quantitative morphology and spatial orientation of dendritic arborisations. J. Comp. Neurol. 227:200-213
- Percheron, G.,Yelnik, J. and François. C. (1984) A Golgi analysis of the primate globus pallidus. III-Spatial organization of the striato-pallidal complex. J. Comp. Neurol. 227: 214-227
- Fox, C.A., Andrade, A.N. Du Qui, I.J., Rafols, J.A. (1974) The primate globus pallidus. A Golgi and electron microscopic study. J. Hirnforsch. 15: 75-93
- di Figlia, M., Pasik, P., Pasik, T. (1982) A Golgi and ultrastructural study of the monkey globus pallidus. J. Comp. Neurol. 212: 53-75
- Surmeier, D.J., Mercer, J.N. and Savio Chan, C. (2005) Autonomous pacemakers in the basal ganglia: who needs excitatory synapses anyway? Cur. Opin.Neurobiol. 15:312-318.
|Wikimedia Commons has media related to: Globus pallidus|
- Globus+pallidus at eMedicine Dictionary
- Paleostriatum at eMedicine Dictionary
- Diagram at uni-tuebingen.de
- NIF Search - Globus Pallidus via the Neuroscience Information Framework
- What Is the Globus Pallidus?