Glomerular basement membrane
From Wikipedia, the free encyclopedia
| Glomerular basement membrane | |
|---|---|
 |
|
| Glomerulus. (Diagram in French, but "Membrane basale glomerulaire et ses podocytes" labeled near center.) | |
 |
|
| Scheme of filtration barrier (blood-urine) in the kidney. A. The endothelial cells of the glomerulus; 1. pore (fenestra). B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragma |
|
| MeSH | glomerular+basement+membrane |
The glomerular basement membrane (GBM) is the basal laminal portion of the glomerulus. The Glomerular capillary endothelial cells, the GBM and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule.[1] The GBM is a fusion of the endothelial cell and podocyte basal laminas. [2]
Contents |
[edit] Layers
The GBM contains three layers: [3]
| Layer | Location | Composition | Function |
| lamina rara externa | adjacent to podocyte processes | heparan sulfate | blocks by charge |
| lamina densa | dark central zone | type 4 collagen and laminin | blocks by size (MW > 69,000) |
| lamina rara interna | adjacent to endothelial cells | heparan sulfate | blocks by charge |
[edit] Pathology
- Goodpasture's syndrome is also known as "anti-glomerular basement membrane disease". Capillaries become inflamed as a result of damage to the basement membrane by antibodies to type 4 collagen.
- Nephrotic syndrome is a change in the structure of the glomerular filtration mechanism usually in the glomerular basement membrane. Some symptoms include proteinuria, hypoalbuminaemia, oedema, and hyperlipidemia.
- Diabetic glomerulosclerosis is a thickening of the basement membrane, which can become up to 4-5 times thicker than normal. Can be caused by insulin deficiency or resultant hyperglycemia.
[edit] See also
[edit] Additional images
-
Renal corpuscle. GBM is #1.
[edit] References
- ^ Jarad, G.; Miner, J. H. (2009). "Update on the glomerular filtration barrier". Current opinion in nephrology and hypertension 18 (3): 226–232. PMC 2895306. PMID 19374010. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2895306.
- ^ Physiology at MCG 7/7ch04/7ch04p07 - "Basement Membrane"
- ^ JCI - New articles published
[edit] External links
- MeSH glomerular+basement+membrane
- "The GBM and its disorders" at dmed.ed.ac.uk
- Histology at harvard.edu
- Structure at wramc.army.mi
 |
This article related to the genitourinary system is a stub. You can help Wikipedia by expanding it. |
|
||||||||||||||||||||||||||||||||||||||||
