are a Glucagon/ GIP/ secretin/ VIP hormones family of evolutionarily related peptide hormones that regulate activity of G-protein coupled receptors from secretin receptor family.
A number of polypeptidic hormones, mainly expressed in the
intestine or the pancreas, belong to a group of these structurally related peptides. [1 ] One such hormone, [2 ] glucagon is widely distributed and produced in the alpha-cells of pancreatic islets. It affects [3 ] glucose metabolism in the liver by inhibiting glycogen synthesis, stimulating glycogenolysis and enchancing gluconeogenesis. It also increases mobilisation of glucose, free [4 ] fatty acids and ketone bodies, which are metabolites produced in excess in diabetes mellitus. Glucagon is produced, like other peptide hormones, as part of a larger precursor (preproglucagon), which is cleaved to produce glucagon, glucagon-like protein I and glucagon-like protein II. The structure of glucagon itself is fully conserved in all mammalian species in which it has been studied. [5 ] Other members of the structurally similar group include glicentin precursor, [3 ] secretin, gastric inhibitory peptide, vasoactive intestinal peptide (VIP), prealbumin, peptide HI-27 and growth hormone releasing factor.
Human hormones from this family [ edit ]
ADCYAP1; GCG; GHRH; GIP; SCT; VIP;
References [ edit ]
^ Mutt V (1988). "Vasoactive intestinal polypeptide and related peptides. Isolation and chemistry". Ann. N.Y. Acad. Sci. 527: 1–19. doi: 10.1111/j.1749-6632.1988.tb26968.x. PMID 3133967.
^ Bataille D, Blache P, Mercier F, Jarrousse C, Kervran A, Dufour M, Mangeat P, Dubrasquet M, Mallat A, Lotersztajn S (1988). "Glucagon and related peptides. Molecular structure and biological specificity". Ann. N.Y. Acad. Sci. 527: 168–185. doi: 10.1111/j.1749-6632.1988.tb26980.x. PMID 3291691.
^ a b Conlon JM, Thim L (1985). "Primary structure of glucagon from an elasmobranchian fish. Torpedo marmorata". General and comparative endocrinology 60 (3): 398–405. doi: 10.1016/0016-6480(85)90073-5. PMID 4076759.
^ Kumar A, Lopez LC, Frazier ML, Su CJ, Saunders GF (1983). "Mammalian pancreatic preproglucagon contains three glucagon-related peptides". Proc. Natl. Acad. Sci. U.S.A. 80 (18): 5485–5489. doi: 10.1073/pnas.80.18.5485. PMC 384282. PMID 6577439.
^ Pollock HG, Hamilton JW, Rouse JB, Ebner KE, Rawitch AB (1988). "Isolation of peptide hormones from the pancreas of the bullfrog (Rana catesbeiana). Amino acid sequences of pancreatic polypeptide, oxyntomodulin, and two glucagon-like peptides". J. Biol. Chem. 263 (20): 9746–9751. PMID 3260236.
This article incorporates text from the public domain Pfam and InterPro IPR000532