Glucosidases

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Glucosidases are glycoside hydrolase enzymes categorized under the EC number 3.2.1.

Function[edit]

α-glucosidases are enzymes involved in breaking down complex carbohydrates such as starch and glycogen

They catalyze the cleavage of individual glucosyl residues from various glycoconjugates including alpha- or beta-linked polymers of glucose.

Members[edit]

Different sources include different members in this class. Members marked with a "#" are considered by MeSH to be glucosidases.

Name EC Description
α-Amylase EC 3.2.1.1 is a digestive enzyme in mammals
β-Amylase EC 3.2.1.2 is a plant enzyme to break down starch
γ-Amylase EC 3.2.1.3 is a digestive enzyme
Cellulase # EC 3.2.1.4 breaks down cellulose from plant material
Sucrase-isomaltase EC 3.2.1.10 -
Acid α-glucosidase # EC 3.2.1.20 is associated with Glycogen storage disease type II
Beta-glucosidase # EC 3.2.1.21 - is associated with gaucher's disease
Lactase EC 3.2.1.23 one member of the β-galactosidase family, breaks down milk sugars, and its absence in adulthood causes lactose intolerance
Debranching enzyme # EC 3.2.1.33 -
Pullulanase EC 3.2.1.41 has been used as a detergent

Clinical significance[edit]

They are targeted by alpha-glucosidase inhibitors such as acarbose and miglitol to control diabetes mellitus type 2.

See also[edit]

External links[edit]