enzymology, a glucosylceramidase ( EC 220.127.116.11) is an enzyme that belongs to Glycoside hydrolase family 30 and catalyzes the chemical reaction
D-glucosyl-N-acylsphingosine + H
2O D-glucose + N-acylsphingosine
Thus, the two
substrates of this enzyme are D-glucosyl-N-acylsphingosine and H, whereas its two 2O products are D-glucose and N-acylsphingosine.
This enzyme belongs to the family of
hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include:
and glucosylsphingosine beta-D-glucosidase.
This enzyme participates in
sphingolipid metabolism and degradation of glycan structures.
Human proteins containing this domain [ edit ]
References [ edit ]
Further reading [ edit ]
Brady RO, Kanfer J, and Shapiro D (1965). "The metabolism of glucocerebrosides: I. Purification and properties of a glucocerebroside-cleaving enzyme from spleen tissue". J. Biol. Chem. 240: 39–43.
Vaccaro AM, Muscillo M, Suzuki K (1985). "Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase". Eur. J. Biochem. 146 (2): 315–21. doi: 10.1111/j.1432-1033.1985.tb08655.x. PMID 3967661.