Glucosylceramidase

From Wikipedia, the free encyclopedia
Jump to: navigation, search
glucosylceramidase
Identifiers
EC number 3.2.1.45
CAS number 37228-64-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a glucosylceramidase (EC 3.2.1.45) is an enzyme that belongs to Glycoside hydrolase family 30 and catalyzes the chemical reaction

D-glucosyl-N-acylsphingosine + H2O \rightleftharpoons D-glucose + N-acylsphingosine

Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H2O, whereas its two products are D-glucose and N-acylsphingosine.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include:

  • psychosine hydrolase,
  • glucosphingosine glucosylhydrolase,
  • GlcCer-beta-glucosidase,
  • beta-D-glucocerebrosidase,
  • glucosylcerebrosidase,
  • beta-glucosylceramidase,
  • ceramide glucosidase,
  • glucocerebrosidase,
  • glucosylsphingosine beta-glucosidase,
  • and glucosylsphingosine beta-D-glucosidase.

This enzyme participates in sphingolipid metabolism and degradation of glycan structures.

Human proteins containing this domain[edit]

References[edit]

Further reading[edit]

  • Brady RO, Kanfer J, and Shapiro D (1965). "The metabolism of glucocerebrosides: I. Purification and properties of a glucocerebroside-cleaving enzyme from spleen tissue". J. Biol. Chem. 240: 39–43. 
  • Vaccaro AM, Muscillo M, Suzuki K (1985). "Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase". Eur. J. Biochem. 146 (2): 315–21. doi:10.1111/j.1432-1033.1985.tb08655.x. PMID 3967661.