Glutathione—homocystine transhydrogenase

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glutathione—homocystine transhydrogenase
Identifiers
EC number 1.8.4.1
CAS number 9029-40-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a glutathione—homocystine transhydrogenase (EC 1.8.4.1) is an enzyme that catalyzes the chemical reaction

2 glutathione + homocystine \rightleftharpoons glutathione disulfide + 2 homocysteine

Thus, the two substrates of this enzyme are glutathione and homocystine, whereas its two products are glutathione disulfide and homocysteine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is glutathione:homocystine oxidoreductase. This enzyme participates in methionine metabolism and glutathione metabolism.

References[edit]

  • Racker E (1955). "Glutathione-homocystine transhydrogenase". J. Biol. Chem. 217 (2): 867–874. PMID 13271447.