Glyceryl behenate

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Glyceryl behenate
Glyceryl behenate.svg
Names
Other names
Glycerol behenate; Glycerin behenate; Glycerol docosanoate
Identifiers
77538-19-3 YesY
30233-64-8 (monoglycerides) YesY
Properties
Variable
Molar mass Variable
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

Glyceryl behenate is a fat used in cosmetics, foods, and oral pharmaceutical formulations. In cosmetics, it is mainly used as a viscosity-increasing agent in emulsions.

In pharmaceutical formulations, glyceryl behenate is mainly used as a tablet and capsule lubricant and as a lipidic coating excipient. It has been investigated for the encapsulation of various drugs such as retinoids. It has also been investigated for use in the preparation of sustained release tablets as a matrix-forming agent for the controlled release of water-soluble drugs and as a lubricant in oral solid dosage formulations. It can also be used as a hot-melt coating agent sprayed onto a powder.[1]

It is used widely in cosmetics as non-comedogenic (non- pimple causing substance) ingredient. It does not clog the oil pores of facial skin.

It is also used widely as ingredient for preparation of lipidic nano-particles such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). Chemically, glyceryl behenate is a mixture of various esters of behenic acid and glycerol (glycerides).[2] The mixture predominately contains the diester glyceryl dibehenate.[2]

See also[edit]

References[edit]

  1. ^ Handbook of pharmaceutical excipient, 5th edition
  2. ^ a b 21 C.F.R. 184.1328