Glycidol
| Glycidol | |
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Oxiranylmethanol |
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Other names
Glycidol |
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| Identifiers | |
| CAS number | 556-52-5  |
| PubChem | 11164 |
| ChemSpider | 10691 |
| KEGG | C10920 |
| ChEBI | CHEBI:30966 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C3H6O2 |
| Molar mass | 74.08 g mol−1 |
| Appearance | Viscous liquid |
| Density | 1.1143 g/cm³[1] |
| Melting point |
−54 °C, 219 K, -65 °F ([2]) |
| Boiling point |
167 °C, 440 K, 333 °F (decomp.[1]) |
| Hazards | |
| MSDS | External MSDS |
| NFPA 704 |
 2
4
3
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| Flash point | 66 °C (151 °F)[2] |
| LD50 | 420 mg/kg (oral, rat)[2][3] 1980 mg/kg (dermal, rabbit)[2][4] |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Glycidol is an organic compound that contains both epoxide and alcohol functional groups. Being bifunctional, it has a variety of industrial uses. The compound is a slightly viscous liquid that is slightly unstable and is not often encountered in pure form.
Contents |
[edit] Synthesis and applications
Glycidol is prepared by the epoxidation of allyl alcohol.[5]
Glycidol is used as a stabilizer for natural oils and vinyl polymers and as a demulsifier. It is used as a chemical intermediate in the synthesis of glycerol, glycidyl ethers, esters and amines. It is used in surface coatings, chemical synthesis, pharmaceuticals, sanitary chemicals and sterilizing milk of magnesia, and as a gelation agent in solid propellants.[6]
[edit] Safety
Glycidol is an irritant of the skin, eyes, mucous membranes, and upper respiratory tract. Exposure to glycidol may also cause central nervous system depression, followed by central nervous system stimulation.[7] It is listed as an IARC group 2A carcinogen, meaning that it is "probably carcinogenic to humans".[8]
[edit] See also
[edit] References
- ^ a b Merck Index, 11th Edition, 4385
- ^ a b c d Record in the GESTIS Substance Database from the IFA
- ^ Food and Cosmetics Toxicology. Vol. 19, Pg. 347, 1981
- ^ AMA Archives of Industrial Health. Vol. 14, Pg. 250, 1956
- ^ Guenter Sienel, Robert Rieth, Kenneth T. Rowbottom "Epoxides" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005. doi:10.1002/14356007.a09_531
- ^ Glycidol at chemicalland21.com
- ^ OSHA guidelines for glycidol
- ^ IARC Monographs - Classifications - Group2A
