Trifunctional purine biosynthetic protein adenosine-3

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Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

PDB rendering based on 1rbm.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GART ; AIRS; GARS; GARTF; PAIS; PGFT; PRGS
External IDs OMIM138440 MGI95654 HomoloGene637 ChEMBL: 3972 GeneCards: GART Gene
EC number 2.1.2.2, 6.3.3.1, 6.3.4.13
Orthologs
Species Human Mouse
Entrez 2618 14450
Ensembl ENSG00000159131 ENSMUSG00000022962
UniProt P22102 Q64737
RefSeq (mRNA) NM_000819 NM_010256
RefSeq (protein) NP_000810 NP_034386
Location (UCSC) Chr 21:
34.88 – 34.92 Mb
Chr 16:
91.62 – 91.65 Mb
PubMed search [1] [2]

Trifunctional purine biosynthetic protein adenosine-3 is an enzyme that in humans is encoded by the GART gene.[1]

This protein is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase (EC 6.3.4.13), phosphoribosylglycinamide synthetase (EC 6.3.3.1), phosphoribosylaminoimidazole synthetase (EC 2.1.2.2) activity which is required for de novo purine biosynthesis.

References[edit]

  1. ^ Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV (July 1991). "Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes". EMBO J. 10 (7): 1629–34. PMC 452831. PMID 2050105. 

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