Glycosuria

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Glycosuria
ICD-10 R81
ICD-9 791.5
DiseasesDB 5323
MeSH D006029

Glycosuria or glucosuria is the excretion of glucose into the urine. Ordinarily, urine contains no glucose because the kidneys are able to reclaim all of the filtered glucose back into the bloodstream. Glycosuria is nearly always caused by elevated blood glucose levels, most commonly due to untreated diabetes mellitus. Rarely, glycosuria is due to an intrinsic problem with glucose reabsorption within the kidneys themselves, a condition termed renal glycosuria.[1] Glycosuria leads to excessive water loss into the urine with resultant dehydration, a process called osmotic diuresis.

Pathophysiology[edit]

Blood is filtered by millions of nephrons, the functional units that comprise the kidneys. In each nephron, blood flows from the arteriole into the glomerulus, a tuft of leaky capillaries. The Bowman's capsule surrounds each glomerulus, and collects the filtrate that the glomerulus forms. The filtrate contains waste products (e.g. urea), electrolytes (e.g. sodium, potassium, chloride), amino acids, and glucose. The filtrate passes into the renal tubules of the kidney. In the first part of the renal tubule, the proximal tubule, glucose is reabsorbed from the filtrate, across the tubular epithelium and into the bloodstream. The proximal tubule can only reabsorb a limited amount of glucose. When the blood glucose level exceeds about 160 – 180 mg/dl, the proximal tubule becomes overwhelmed and begins to excrete glucose in the urine.

Approximate correlation between dipstick designation and plasma concentration of glucose
Urine dipstick
designation
Approximate plasma
concentration
trace 100 mg/dL [2]
1+ 250 mg/dL[2]df
2+ 500 mg/dL[2]
3+ 1000 mg/dL[2]
4+ 2000 mg/dL[2]

This point is called the renal threshold of glucose (RTG).[3] Some people, especially children and pregnant women, may have a low RTG (less than ~7 mmol/L[3] glucose in blood to have glucosuria).

If the RTG is so low that even normal blood glucose levels produce the condition, it is referred to as renal glycosuria.

Glucose in urine can be identified by Benedict's qualitative test.

A urine dipstick can show a false-positive glucosuria if someone is taking Pyridium or AZO Standard, medications that relieve symptoms of urinary tract infection.

References[edit]

  1. ^ Rose, Burton; Rennke, Helmut (1994). Renal pathophysiology - the essentials (1st ed ed.). Philadelphia: Lippincott Williams & Wilkins. p. 194. ISBN 0-683-07354-0. 
  2. ^ a b c d e Han BR, Oh YS, Ahn KH, Kim HY, Hong SC, Oh MJ, Kim HJ, Kim YT, Lee KW, Kim SH. BR, Han (Sep 2010). "Clinical Implication of 2nd Trimester Glycosuria.". Korean J Perinatol. 21 (3): 258–265.  [1] [2]
  3. ^ a b AIDA on-line' Explanations

See also[edit]