Gmina Sieroszewice is a rural gmina (administrative district) in Ostrów Wielkopolski County, Greater Poland Voivodeship, in west-central Poland. Its seat is the village of Sieroszewice, which lies approximately 19 kilometres (12 mi) east of Ostrów Wielkopolski and 112 km (70 mi) south-east of the regional capital Poznań.
The gmina covers an area of 163.54 square kilometres (63.1 sq mi), and as of 2006 its total population is 9,605.
Gmina Sieroszewice contains the villages and settlements of Bibianki, Biernacice, Bilczew, Kania, Latowice, Masanów, Namysłaki, Ołobok, Parczew, Psary, Raduchów, Rososzyca, Sieroszewice, Sławin, Strzyżew, Westrza, Wielowieś and Zamość.
Gmina Sieroszewice is bordered by the gminas of Brzeziny, Godziesze Wielkie, Grabów nad Prosną, Kraszewice, Mikstat, Nowe Skalmierzyce, Ostrów Wielkopolski and Przygodzice.