"Go D.J." is the second single from Lil Wayne's fourth studio album, Tha Carter. The single's famous beat is produced by DJ Mannie Fresh, who also provides vocals in the song. The lyrics to the song are both written and performed by Lil Wayne. The single became Lil Wayne's first solo hit, reaching the top three on the US Rap Charts and becoming a top 40 single. The song was Lil Wayne's most successful single as a lead artist until "Lollipop" reached number one in 2008.
The song's chorus is borrowed from an earlier song of the same title by New Orleans rap group U.N.L.V.
The song has been sampled numerous times, especially in later Lil Wayne tracks.